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Synthesis of 9-Hydroxy-1H-Benzo[f]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, P-Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects.
Albalawi FF, El-Nassag MAA, El-Eisawy RA, Mohamed MBI, Fouda AM, Afifi TH, Elhenawy AA, Mora A, El-Agrody AM, El-Mawgoud HKA. Albalawi FF, et al. Among authors: el nassag maa. Int J Mol Sci. 2022 Dec 20;24(1):49. doi: 10.3390/ijms24010049. Int J Mol Sci. 2022. PMID: 36613493 Free PMC article.
Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.
Ahmed HEA, El-Nassag MAA, Hassan AH, Okasha RM, Ihmaid S, Fouda AM, Afifi TH, Aljuhani A, El-Agrody AM. Ahmed HEA, et al. Among authors: el nassag maa. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1074-1088. doi: 10.1080/14756366.2018.1476503. J Enzyme Inhib Med Chem. 2018. PMID: 29923425 Free PMC article.
Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene.
Alblewi FF, Okasha RM, Hritani ZM, Mohamed HM, El-Nassag MAA, Halawa AH, Mora A, Fouda AM, Assiri MA, Al-Dies AM, Afifi TH, El-Agrody AM. Alblewi FF, et al. Among authors: el nassag maa. Bioorg Chem. 2019 Jun;87:560-571. doi: 10.1016/j.bioorg.2019.03.059. Epub 2019 Mar 22. Bioorg Chem. 2019. PMID: 30928878
Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels.
Al-Harbi LM, Al-Harbi EA, Okasha RM, El-Eisawy RA, El-Nassag MAA, Mohamed HM, Fouda AM, Elhenawy AA, Mora A, El-Agrody AM, El-Mawgoud HKA. Al-Harbi LM, et al. Among authors: el nassag maa. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2155814. doi: 10.1080/14756366.2022.2155814. J Enzyme Inhib Med Chem. 2023. PMID: 36662632 Free PMC article.
Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Abd El-Wahab AHF, Borik RMA, Al-Dies AM, Fouda AM, Mohamed HM, El-Eisawy RA, Mora A, El-Nassag MAA, Abd Elhady AM, Elhenawy AA, El-Agrody AM. Abd El-Wahab AHF, et al. Among authors: el nassag maa. Sci Rep. 2024 Mar 31;14(1):7589. doi: 10.1038/s41598-024-56197-w. Sci Rep. 2024. PMID: 38555345 Free PMC article.