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Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
Zhou J, De Jonghe S, Codd EE, Weiner S, Gallacher D, Stahle P, Kelley MF, Kuffner EK, Flores CM, Eichenbaum GE. Zhou J, et al. Among authors: de jonghe s. Regul Toxicol Pharmacol. 2023 Jan 4:105334. doi: 10.1016/j.yrtph.2023.105334. Online ahead of print. Regul Toxicol Pharmacol. 2023. PMID: 36608923 Free article.
Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct.
Movita D, van de Garde MD, Biesta P, Kreefft K, Haagmans B, Zuniga E, Herschke F, De Jonghe S, Janssen HL, Gama L, Boonstra A, Vanwolleghem T. Movita D, et al. Among authors: de jonghe s. J Virol. 2015 May;89(9):4809-17. doi: 10.1128/JVI.03733-14. Epub 2015 Feb 11. J Virol. 2015. PMID: 25673700 Free PMC article.
Methods to evaluate and improve the injection site tolerability of intravenous formulations prior to first-in-human testing.
Eichenbaum G, Zhou J, De Smedt A, De Jonghe S, Looszova A, Arien T, Van Goethem F, Vervoort I, Shukla U, Lammens L. Eichenbaum G, et al. Among authors: de jonghe s, de smedt a. J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):394-406. doi: 10.1016/j.vascn.2013.08.002. Epub 2013 Aug 8. J Pharmacol Toxicol Methods. 2013. PMID: 23933112
Timing is everything for sperm assessment in fertility studies.
Mariën D, Bailey GP, Eichenbaum G, De Jonghe S. Mariën D, et al. Among authors: de jonghe s. Reprod Toxicol. 2016 Sep;64:141-50. doi: 10.1016/j.reprotox.2016.05.001. Epub 2016 May 12. Reprod Toxicol. 2016. PMID: 27181369
Testing of acetaminophen in support of the international multilaboratory in vivo rat Pig-a assay validation trial.
van der Leede BJ, Weiner S, Van Doninck T, De Vlieger K, Schuermans A, Tekle F, Geys H, van Heerden M, De Jonghe S, Van Gompel J. van der Leede BJ, et al. Among authors: de jonghe s, de vlieger k. Environ Mol Mutagen. 2020 Jun;61(5):508-525. doi: 10.1002/em.22368. Epub 2020 Apr 15. Environ Mol Mutagen. 2020. PMID: 32187737 Free PMC article.
Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop.
Ramirez T, Beken S, Chlebus M, Ellis G, Griesinger C, De Jonghe S, Manou I, Mehling A, Reisinger K, Rossi LH, van Benthem J, van der Laan JW, Weissenhorn R, Sauer UG. Ramirez T, et al. Among authors: de jonghe s. Regul Toxicol Pharmacol. 2015 Oct;73(1):210-26. doi: 10.1016/j.yrtph.2015.07.007. Epub 2015 Jul 15. Regul Toxicol Pharmacol. 2015. PMID: 26188116
148 results