Shimizu T - Search Results

1

Editorial: Frontiers on innate immunity and intercellular communication.

Xiao Y, Zhang Y, Yin H, Shimizu T. Xiao Y, et al. Among authors: shimizu t. Front Immunol. 2022 Dec 19;13:1102776. doi: 10.3389/fimmu.2022.1102776. eCollection 2022. Front Immunol. 2022. PMID: 36601123 Free PMC article. No abstract available.

2

Small-molecule inhibition of TLR8 through stabilization of its resting state.

Zhang S, Hu Z, Tanji H, Jiang S, Das N, Li J, Sakaniwa K, Jin J, Bian Y, Ohto U, Shimizu T, Yin H. Zhang S, et al. Among authors: shimizu t. Nat Chem Biol. 2018 Jan;14(1):58-64. doi: 10.1038/nchembio.2518. Epub 2017 Nov 20. Nat Chem Biol. 2018. PMID: 29155428 Free PMC article.

3

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.

Hu Z, Tanji H, Jiang S, Zhang S, Koo K, Chan J, Sakaniwa K, Ohto U, Candia A, Shimizu T, Yin H. Hu Z, et al. Among authors: shimizu t. Cell Chem Biol. 2018 Oct 18;25(10):1286-1291.e3. doi: 10.1016/j.chembiol.2018.07.004. Epub 2018 Aug 9. Cell Chem Biol. 2018. PMID: 30100350 Free PMC article.

4

Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8.

Padilla-Salinas R, Anderson R, Sakaniwa K, Zhang S, Nordeen P, Lu C, Shimizu T, Yin H. Padilla-Salinas R, et al. Among authors: shimizu t. J Med Chem. 2019 Nov 27;62(22):10221-10244. doi: 10.1021/acs.jmedchem.9b01201. Epub 2019 Nov 18. J Med Chem. 2019. PMID: 31687820

5

Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.

Jiang S, Tanji H, Yin K, Zhang S, Sakaniwa K, Huang J, Yang Y, Li J, Ohto U, Shimizu T, Yin H. Jiang S, et al. Among authors: shimizu t. J Med Chem. 2020 Apr 23;63(8):4117-4132. doi: 10.1021/acs.jmedchem.9b02128. Epub 2020 Apr 13. J Med Chem. 2020. PMID: 32233366

6

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.

Yang Y, Csakai A, Jiang S, Smith C, Tanji H, Huang J, Jones T, Sakaniwa K, Broadwell L, Shi C, Soti S, Ohto U, Fang Y, Shen S, Deng F, Shimizu T, Yin H. Yang Y, et al. Among authors: shimizu t. Nat Commun. 2021 Jul 16;12(1):4351. doi: 10.1038/s41467-021-24536-4. Nat Commun. 2021. PMID: 34272380 Free PMC article.

7

[Structural Analyses of Toll-like Receptor Sensing Single-stranded Nucleic Acids and Its Application].

Shimizu T. Shimizu T. Yakugaku Zasshi. 2016;136(2):173-8. doi: 10.1248/yakushi.15-00229-1. Yakugaku Zasshi. 2016. PMID: 26831789 Free article. Review. Japanese.

8

Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids.

Miyake K, Shibata T, Ohto U, Shimizu T. Miyake K, et al. Among authors: shimizu t. J Leukoc Biol. 2017 Jan;101(1):135-142. doi: 10.1189/jlb.4MR0316-108R. Epub 2016 Jun 22. J Leukoc Biol. 2017. PMID: 27334229 Review.

9

Toward a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system.

Zhang Z, Ohto U, Shimizu T. Zhang Z, et al. Among authors: shimizu t. FEBS Lett. 2017 Oct;591(20):3167-3181. doi: 10.1002/1873-3468.12749. Epub 2017 Jul 21. FEBS Lett. 2017. PMID: 28686285 Free article. Review.

10

Mechanisms controlling nucleic acid-sensing Toll-like receptors.

Miyake K, Shibata T, Ohto U, Shimizu T, Saitoh SI, Fukui R, Murakami Y. Miyake K, et al. Among authors: shimizu t. Int Immunol. 2018 Mar 8;30(2):43-51. doi: 10.1093/intimm/dxy016. Int Immunol. 2018. PMID: 29452403 Review.

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