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KIF1A is kinetically tuned to be a superengaging motor under hindering loads.
Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2216903120. doi: 10.1073/pnas.2216903120. Epub 2023 Jan 4.
Proc Natl Acad Sci U S A. 2023.
PMID: 36598948
Free PMC article.
Positive charge in the K-loop of the kinesin-3 motor KIF1A regulates superprocessivity by enhancing microtubule affinity in the one-head-bound state.
Zaniewski TM, Hancock WO.
Zaniewski TM, et al.
J Biol Chem. 2023 Feb;299(2):102818. doi: 10.1016/j.jbc.2022.102818. Epub 2022 Dec 20.
J Biol Chem. 2023.
PMID: 36549649
Free PMC article.
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Synergy between inhibitors of two mitotic spindle assembly motors undermines an adaptive response.
Solon AL, Zaniewski TM, O'Brien P, Clasby M, Hancock WO, Ohi R.
Solon AL, et al. Among authors: zaniewski tm.
Mol Biol Cell. 2022 Dec 1;33(14):ar132. doi: 10.1091/mbc.E22-06-0225. Epub 2022 Oct 6.
Mol Biol Cell. 2022.
PMID: 36200902
Free PMC article.
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A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle.
Zaniewski TM, Gicking AM, Fricks J, Hancock WO.
Zaniewski TM, et al.
J Biol Chem. 2020 Dec 25;295(52):17889-17903. doi: 10.1074/jbc.RA120.014961. Epub 2020 Oct 20.
J Biol Chem. 2020.
PMID: 33082143
Free PMC article.
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