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Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins.
Alonso-Lerma B, Jabalera Y, Samperio S, Morin M, Fernandez A, Hille LT, Silverstein RA, Quesada-Ganuza A, Reifs A, Fernández-Peñalver S, Benitez Y, Soletto L, Gavira JA, Diaz A, Vranken W, Sanchez-Mejias A, Güell M, Mojica FJM, Kleinstiver BP, Moreno-Pelayo MA, Montoliu L, Perez-Jimenez R. Alonso-Lerma B, et al. Among authors: perez jimenez r. Nat Microbiol. 2023 Jan;8(1):77-90. doi: 10.1038/s41564-022-01265-y. Epub 2023 Jan 2. Nat Microbiol. 2023. PMID: 36593295 Free PMC article.
Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis.
Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM. Perez-Jimenez R, et al. J Biol Chem. 2008 Oct 3;283(40):27121-9. doi: 10.1074/jbc.M803746200. Epub 2008 Aug 7. J Biol Chem. 2008. PMID: 18687682 Free PMC article.
Conservation of protein structure over four billion years.
Ingles-Prieto A, Ibarra-Molero B, Delgado-Delgado A, Perez-Jimenez R, Fernandez JM, Gaucher EA, Sanchez-Ruiz JM, Gavira JA. Ingles-Prieto A, et al. Structure. 2013 Sep 3;21(9):1690-7. doi: 10.1016/j.str.2013.06.020. Epub 2013 Aug 8. Structure. 2013. PMID: 23932589 Free PMC article.
High-throughput virtual search of small molecules for controlling the mechanical stability of human CD4.
Reifs A, Fernandez-Calvo A, Alonso-Lerma B, Schönfelder J, Franco D, Ortega-Muñoz M, Casares S, Jimenez-Lopez C, Saa L, Cortajarena AL, De Sancho D, San Sebastian E, Perez-Jimenez R. Reifs A, et al. Among authors: perez jimenez r. J Biol Chem. 2024 Apr;300(4):107133. doi: 10.1016/j.jbc.2024.107133. Epub 2024 Mar 2. J Biol Chem. 2024. PMID: 38432632 Free PMC article.
Probing the chemistry of thioredoxin catalysis with force.
Wiita AP, Perez-Jimenez R, Walther KA, Gräter F, Berne BJ, Holmgren A, Sanchez-Ruiz JM, Fernandez JM. Wiita AP, et al. Nature. 2007 Nov 1;450(7166):124-7. doi: 10.1038/nature06231. Nature. 2007. PMID: 17972886 Free PMC article.
79 results