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Page 1
Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist.
Decker AM, Brackeen MF, Mohammadkhani A, Kormos CM, Hesk D, Borgland SL, Blough BE. Decker AM, et al. Among authors: hesk d. ACS Chem Neurosci. 2022 Apr 6;13(7):1082-1095. doi: 10.1021/acschemneuro.2c00086. Epub 2022 Mar 24. ACS Chem Neurosci. 2022. PMID: 35325532 Free PMC article.
The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease.
Li W, Wang Y, Lohith TG, Zeng Z, Tong L, Mazzola R, Riffel K, Miller P, Purcell M, Holahan M, Haley H, Gantert L, Hesk D, Ren S, Morrow J, Uslaner J, Struyk A, Wai JM, Rudd MT, Tellers DM, McAvoy T, Bormans G, Koole M, Van Laere K, Serdons K, de Hoon J, Declercq R, De Lepeleire I, Pascual MB, Zanotti-Fregonara P, Yu M, Arbones V, Masdeu JC, Cheng A, Hussain A, Bueters T, Anderson MS, Hostetler ED, Basile AS. Li W, et al. Among authors: hesk d. Sci Transl Med. 2022 Jan 12;14(627):eabg3684. doi: 10.1126/scitranslmed.abg3684. Epub 2022 Jan 12. Sci Transl Med. 2022. PMID: 35020407
Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery.
Pipal RW, Stout KT, Musacchio PZ, Ren S, Graham TJA, Verhoog S, Gantert L, Lohith TG, Schmitz A, Lee HS, Hesk D, Hostetler ED, Davies IW, MacMillan DWC. Pipal RW, et al. Among authors: hesk d. Nature. 2021 Jan;589(7843):542-547. doi: 10.1038/s41586-020-3015-0. Epub 2020 Nov 25. Nature. 2021. PMID: 33238289 Free PMC article.
Hydrogen isotope exchange labelling: A brief update.
Derdau V, Hesk D. Derdau V, et al. Among authors: hesk d. J Labelled Comp Radiopharm. 2020 May 30;63(6):246. doi: 10.1002/jlcr.3843. Epub 2020 May 4. J Labelled Comp Radiopharm. 2020. PMID: 32330319 No abstract available.
Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases.
Tong L, Li W, Lo MM, Gao X, Wai JM, Rudd M, Tellers D, Joshi A, Zeng Z, Miller P, Salinas C, Riffel K, Haley H, Purcell M, Holahan M, Gantert L, Schubert JW, Jones K, Mulhearn J, Egbertson M, Meng Z, Hanney B, Gomez R, Harrison ST, McQuade P, Bueters T, Uslaner J, Morrow J, Thomson F, Kong J, Liao J, Selyutin O, Bao J, Hastings NB, Agrawal S, Magliaro BC, Monsma FJ Jr, Smith MD, Risso S, Hesk D, Hostetler E, Mazzola R. Tong L, et al. Among authors: hesk d. J Med Chem. 2020 Mar 12;63(5):2411-2425. doi: 10.1021/acs.jmedchem.9b01406. Epub 2020 Mar 3. J Med Chem. 2020. PMID: 32101422 Free article.
Synthesis of [3 H] and [14 C]genipin.
Queen AE, Hesk D, Lindsay DM, Kerr WJ, Rehder K, Fennell T, Mascarella W, Zhong D, Runyon S. Queen AE, et al. Among authors: hesk d. J Labelled Comp Radiopharm. 2020 Apr;63(4):196-202. doi: 10.1002/jlcr.3832. Epub 2020 Feb 11. J Labelled Comp Radiopharm. 2020. PMID: 32017204 Free article.
Base metal-catalyzed hydrogen isotope exchange.
Yang H, Hesk D. Yang H, et al. Among authors: hesk d. J Labelled Comp Radiopharm. 2020 May 30;63(6):296-307. doi: 10.1002/jlcr.3826. Epub 2020 Feb 3. J Labelled Comp Radiopharm. 2020. PMID: 31950546
54 results