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The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M. Higashikuni Y, et al. Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2128-35. doi: 10.1161/ATVBAHA.110.211755. Epub 2010 Sep 9. Arterioscler Thromb Vasc Biol. 2010. PMID: 20829509
The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Tanaka K, Sahara M, Hirata Y, Nagai R, Sata M. Higashikuni Y, et al. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):654-61. doi: 10.1161/ATVBAHA.111.240341. Epub 2011 Nov 23. Arterioscler Thromb Vasc Biol. 2012. PMID: 22116099
Endothelial PGC-1α mediates vascular dysfunction in diabetes.
Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Sawada N, et al. Among authors: higashikuni y. Cell Metab. 2014 Feb 4;19(2):246-58. doi: 10.1016/j.cmet.2013.12.014. Cell Metab. 2014. PMID: 24506866 Free PMC article.
64 results