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LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence.
Konopa A, Meier MA, Franz MJ, Bernardinelli E, Voegele AL, Atreya R, Ribback S, Roessler S, Aigner A, Singer K, Singer S, Sarikas A, Muehlich S. Konopa A, et al. Among authors: muehlich s. Oncogenesis. 2022 Dec 28;11(1):69. doi: 10.1038/s41389-022-00445-z. Oncogenesis. 2022. PMID: 36577757 Free PMC article.
Tetraspanin 5 (TSPAN5), a Novel Gatekeeper of the Tumor Suppressor DLC1 and Myocardin-Related Transcription Factors (MRTFs), Controls HCC Growth and Senescence.
Schreyer L, Mittermeier C, Franz MJ, Meier MA, Martin DE, Maier KC, Huebner K, Schneider-Stock R, Singer S, Holzer K, Fischer D, Ribback S, Liebl B, Gudermann T, Aigner A, Muehlich S. Schreyer L, et al. Among authors: muehlich s. Cancers (Basel). 2021 Oct 26;13(21):5373. doi: 10.3390/cancers13215373. Cancers (Basel). 2021. PMID: 34771537 Free PMC article.
Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.
Hampl V, Martin C, Aigner A, Hoebel S, Singer S, Frank N, Sarikas A, Ebert O, Prywes R, Gudermann T, Muehlich S. Hampl V, et al. Among authors: muehlich s. EMBO Mol Med. 2013 Sep;5(9):1367-82. doi: 10.1002/emmm.201202406. Epub 2013 Jul 29. EMBO Mol Med. 2013. PMID: 23853104 Free PMC article.
The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma.
Hermanns C, Hampl V, Holzer K, Aigner A, Penkava J, Frank N, Martin DE, Maier KC, Waldburger N, Roessler S, Goppelt-Struebe M, Akrap I, Thavamani A, Singer S, Nordheim A, Gudermann T, Muehlich S. Hermanns C, et al. Among authors: muehlich s. Oncogene. 2017 Jun 15;36(24):3464-3476. doi: 10.1038/onc.2016.496. Epub 2017 Jan 23. Oncogene. 2017. PMID: 28114277
Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity.
Voringer S, Schreyer L, Nadolni W, Meier MA, Woerther K, Mittermeier C, Ferioli S, Singer S, Holzer K, Zierler S, Chubanov V, Liebl B, Gudermann T, Muehlich S. Voringer S, et al. Among authors: muehlich s. Oncogene. 2020 Mar;39(11):2328-2344. doi: 10.1038/s41388-019-1140-8. Epub 2019 Dec 16. Oncogene. 2020. PMID: 31844251
Inhibition of Cullin-RING E3 ubiquitin ligase 7 by simian virus 40 large T antigen.
Hartmann T, Xu X, Kronast M, Muehlich S, Meyer K, Zimmermann W, Hurwitz J, Pan ZQ, Engelhardt S, Sarikas A. Hartmann T, et al. Among authors: muehlich s. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3371-6. doi: 10.1073/pnas.1401556111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550499 Free PMC article.
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