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Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
Rossman EI, Wisialowski TA, Vargas HM, Valentin JP, Rolf MG, Roche BM, Riley S, Pugsley MK, Nichols J, Li D, Leishman DJ, Kleiman RB, Greiter-Wilke A, Gintant GA, Engwall MJ, Delaunois A, Authier S. Rossman EI, et al. Among authors: vargas hm. J Pharmacol Toxicol Methods. 2023 Sep-Oct;123:107270. doi: 10.1016/j.vascn.2023.107270. Epub 2023 May 8. J Pharmacol Toxicol Methods. 2023. PMID: 37164235
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
Vargas HM, Rossman EI, Wisialowski TA, Nichols J, Pugsley MK, Roche B, Gintant GA, Greiter-Wilke A, Kleiman RB, Valentin JP, Leishman DJ. Vargas HM, et al. J Pharmacol Toxicol Methods. 2023 May-Jun;121:107265. doi: 10.1016/j.vascn.2023.107265. Epub 2023 Mar 28. J Pharmacol Toxicol Methods. 2023. PMID: 36997076 Free article. Review.
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment.
Wisialowski TA, Ether N, Foley CM, Kleiman R, Koshman Y, Leishman D, Martel E, Nichols JV, Popp J, Rajamani S, Riley S, Rossman EI, Vargas HM. Wisialowski TA, et al. Among authors: vargas hm. J Pharmacol Toxicol Methods. 2024 May 20;128:107515. doi: 10.1016/j.vascn.2024.107515. Online ahead of print. J Pharmacol Toxicol Methods. 2024. PMID: 38777240 No abstract available.
The Challenges of Predicting Drug-Induced QTc Prolongation in Humans.
Valentin JP, Hoffmann P, Ortemann-Renon C, Koerner J, Pierson J, Gintant G, Willard J, Garnett C, Skinner M, Vargas HM, Wisialowski T, Pugsley MK. Valentin JP, et al. Among authors: vargas hm. Toxicol Sci. 2022 Apr 26;187(1):3-24. doi: 10.1093/toxsci/kfac013. Toxicol Sci. 2022. PMID: 35148401 Free PMC article. Review.
Key Characteristics of Cardiovascular Toxicants.
Lind L, Araujo JA, Barchowsky A, Belcher S, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT. Lind L, et al. Among authors: vargas hm. Environ Health Perspect. 2021 Sep;129(9):95001. doi: 10.1289/EHP9321. Epub 2021 Sep 24. Environ Health Perspect. 2021. PMID: 34558968 Free PMC article.
Corrigendum to "The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies" [Journal of Pharmacological and Toxicological Methods 109 (2021) 107067].
Baublits J, Vargas HM, Engwall MJ. Baublits J, et al. Among authors: vargas hm. J Pharmacol Toxicol Methods. 2021 Nov-Dec;112:107104. doi: 10.1016/j.vascn.2021.107104. Epub 2021 Jul 30. J Pharmacol Toxicol Methods. 2021. PMID: 34334315 No abstract available.
90 results