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Theorizing the Role of Dopaminergic Polymorphic Risk Alleles with Intermittent Explosive Disorder (IED), Violent/Aggressive Behavior and Addiction: Justification of Genetic Addiction Risk Severity (GARS) Testing.
Modestino EJ, Blum K, Dennen CA, Downs BW, Bagchi D, Llanos-Gomez L, Elman I, Baron D, Thanos PK, Badgaiyan RD, Braverman ER, Gupta A, Gold MS, Bowirrat A. Modestino EJ, et al. Among authors: downs bw. J Pers Med. 2022 Nov 23;12(12):1946. doi: 10.3390/jpm12121946. J Pers Med. 2022. PMID: 36556167 Free PMC article.
A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration.
Blum K, Kazmi S, Modestino EJ, Downs BW, Bagchi D, Baron D, McLaughlin T, Green R, Jalali R, Thanos PK, Elman I, Badgaiyan RD, Bowirrat A, Gold MS. Blum K, et al. Among authors: downs bw. J Pers Med. 2021 Mar 16;11(3):212. doi: 10.3390/jpm11030212. J Pers Med. 2021. PMID: 33809702 Free PMC article. Review.
Statistical Validation of Risk Alleles in Genetic Addiction Risk Severity (GARS) Test: Early Identification of Risk for Alcohol Use Disorder (AUD) in 74,566 Case-Control Subjects.
Blum K, Han D, Gupta A, Baron D, Braverman ER, Dennen CA, Kazmi S, Llanos-Gomez L, Badgaiyan RD, Elman I, Thanos PK, Downs BW, Bagchi D, Gondre-Lewis MC, Gold MS, Bowirrat A. Blum K, et al. Among authors: downs bw. J Pers Med. 2022 Aug 26;12(9):1385. doi: 10.3390/jpm12091385. J Pers Med. 2022. PMID: 36143170 Free PMC article.
DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave® and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of "Dopamine Homeostasis" in the Face of the Opioid Crisis.
Bajaj A, Blum K, Bowirrat A, Gupta A, Baron D, Fugel D, Nicholson A, Fitch T, Downs BW, Bagchi D, Dennen CA, Badgaiyan RD. Bajaj A, et al. Among authors: downs bw. J Pers Med. 2022 Aug 30;12(9):1416. doi: 10.3390/jpm12091416. J Pers Med. 2022. PMID: 36143203 Free PMC article.
Should Reward Deficiency Syndrome (RDS) Be Considered an Umbrella Disorder for Mental Illness and Associated Genetic and Epigenetic Induced Dysregulation of Brain Reward Circuitry?
Blum K, Dennen CA, Elman I, Bowirrat A, Thanos PK, Badgaiyan RD, Downs BW, Bagchi D, Baron D, Braverman ER, Gupta A, Green R, McLaughlin T, Barh D, Gold MS. Blum K, et al. Among authors: downs bw. J Pers Med. 2022 Oct 14;12(10):1719. doi: 10.3390/jpm12101719. J Pers Med. 2022. PMID: 36294858 Free PMC article.
Genetic Addiction Risk Severity Assessment Identifies Polymorphic Reward Genes as Antecedents to Reward Deficiency Syndrome (RDS) Hypodopaminergia's Effect on Addictive and Non-Addictive Behaviors in a Nuclear Family.
Dennen CA, Blum K, Bowirrat A, Thanos PK, Elman I, Ceccanti M, Badgaiyan RD, McLaughlin T, Gupta A, Bajaj A, Baron D, Downs BW, Bagchi D, Gold MS. Dennen CA, et al. Among authors: downs bw. J Pers Med. 2022 Nov 8;12(11):1864. doi: 10.3390/jpm12111864. J Pers Med. 2022. PMID: 36579592 Free PMC article.
Would induction of dopamine homeostasis via coupling genetic addiction risk score (GARS®) and pro-dopamine regulation benefit benzodiazepine use disorder (BUD)?
Blum K, Gold M, Modestino EJ, Baron D, Boyett B, Siwicki D, Lott L, Podesta A, Roy AK, Hauser M, Downs BW, Badgaiyan RD. Blum K, et al. Among authors: downs bw. J Syst Integr Neurosci. 2018 May 3;4:10.15761/JSIN.1000196. doi: 10.15761/JSIN.1000196. J Syst Integr Neurosci. 2018. PMID: 31750006 Free PMC article.
Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD).
Blum K, Bowirrat A, Baron D, Lott L, Ponce JV, Brewer R, Siwicki D, Boyett B, Gondre-Lewis MC, Smith DE, Panayotis K T, Badgaiyan S, Hauser M, Fried L, A R 3rd, Downs BW, Badgaiyan RD. Blum K, et al. Among authors: downs bw. J Syst Integr Neurosci. 2020 Aug;6(2):10.15761/JSIN.1000221. doi: 10.15761/JSIN.1000221. Epub 2019 Dec 19. J Syst Integr Neurosci. 2020. PMID: 33614164 Free PMC article.
High Genetic Addiction Risk Score (GARS) in Chronically Prescribed Severe Chronic Opioid Probands Attending Multi-pain Clinics: an Open Clinical Pilot Trial.
Moran M, Blum K, Ponce JV, Lott L, Gondré-Lewis MC, Badgaiyan S, Brewer R, Downs BW, Fynman P, Weingarten A, Cadet JL, Smith DE, Baron D, Thanos PK, Modestino EJ, Badgaiyan RD, Elman I, Gold MS. Moran M, et al. Among authors: downs bw. Mol Neurobiol. 2021 Jul;58(7):3335-3346. doi: 10.1007/s12035-021-02312-1. Epub 2021 Mar 8. Mol Neurobiol. 2021. PMID: 33683627 Free PMC article. Clinical Trial.
79 results