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Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, Capietto AH, Cubas R, Modrusan Z, Sandoval W, Ziai J, Gould SE, Fu W, Wang Y, Koerber JT, Sanjabi S, Mellman I, Turley SJ, Müller S. Castiglioni A, et al. Among authors: himmels p. Nat Commun. 2023 Aug 5;14(1):4703. doi: 10.1038/s41467-023-40398-4. Nat Commun. 2023. PMID: 37543621 Free PMC article.
Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.
Vieira JR, Shah B, Dupraz S, Paredes I, Himmels P, Schermann G, Adler H, Motta A, Gärtner L, Navarro-Aragall A, Ioannou E, Dyukova E, Bonnavion R, Fischer A, Bonanomi D, Bradke F, Ruhrberg C, Ruiz de Almodóvar C. Vieira JR, et al. Among authors: himmels p. Neuron. 2022 Dec 21;110(24):4074-4089.e6. doi: 10.1016/j.neuron.2022.12.005. Neuron. 2022. PMID: 36549270 Free PMC article.
Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis.
Kurtova AV, Heinlein M, Haas S, Velten L, Dijkgraaf GJP, Storm EE, Kljavin NM, Boumahdi S, Himmels P, Herault A, Mancini A, Koeppen H, Dail M, Yan Q, Zhang J, Koch U, Radtke F, Modrusan Z, Metcalfe C, Piskol R, de Sauvage FJ. Kurtova AV, et al. Among authors: himmels p. Blood Adv. 2023 Feb 28;7(4):491-507. doi: 10.1182/bloodadvances.2022007714. Blood Adv. 2023. PMID: 35914228 Free PMC article.
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre L, Mellman I. Tahtinen S, et al. Among authors: himmels p. Nat Immunol. 2022 Apr;23(4):532-542. doi: 10.1038/s41590-022-01160-y. Epub 2022 Mar 24. Nat Immunol. 2022. PMID: 35332327
MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity.
Esen E, Sergin I, Jesudason R, Himmels P, Webster JD, Zhang H, Xu M, Piskol R, McNamara E, Gould S, Capietto AH, Delamarre L, Walsh K, Ye W. Esen E, et al. Among authors: himmels p. Sci Immunol. 2020 Mar 27;5(45):eaay2245. doi: 10.1126/sciimmunol.aay2245. Sci Immunol. 2020. PMID: 32220977
Neurovascular Communication during CNS Development.
Paredes I, Himmels P, Ruiz de Almodóvar C. Paredes I, et al. Among authors: himmels p. Dev Cell. 2018 Apr 9;45(1):10-32. doi: 10.1016/j.devcel.2018.01.023. Dev Cell. 2018. PMID: 29634931 Free article. Review.
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