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Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, Ovens AJ, Tjin G, McAloon LM, Yu D, Ling NXY, Sanders MJ, Oakhill JS, Scott JW, Steinberg GR, Loh K, Kemp BE, Sakamoto K, Galic S. Neopane K, et al. Among authors: sakamoto k. Cell Rep. 2022 Dec 20;41(12):111862. doi: 10.1016/j.celrep.2022.111862. Cell Rep. 2022. PMID: 36543129 Free article.
The ancient drug salicylate directly activates AMP-activated protein kinase.
Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. Hawley SA, et al. Among authors: sakamoto k. Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19. Science. 2012. PMID: 22517326 Free PMC article.
Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK.
Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Hunter RW, et al. Among authors: sakamoto k. Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014. Chem Biol. 2014. PMID: 25036776 Free PMC article.
Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate.
Ducommun S, Deak M, Sumpton D, Ford RJ, Núñez Galindo A, Kussmann M, Viollet B, Steinberg GR, Foretz M, Dayon L, Morrice NA, Sakamoto K. Ducommun S, et al. Among authors: sakamoto k. Cell Signal. 2015 May;27(5):978-88. doi: 10.1016/j.cellsig.2015.02.008. Epub 2015 Feb 13. Cell Signal. 2015. PMID: 25683918 Free article.
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.
Mottillo EP, Desjardins EM, Crane JD, Smith BK, Green AE, Ducommun S, Henriksen TI, Rebalka IA, Razi A, Sakamoto K, Scheele C, Kemp BE, Hawke TJ, Ortega J, Granneman JG, Steinberg GR. Mottillo EP, et al. Among authors: sakamoto k. Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006. Cell Metab. 2016. PMID: 27411013 Free PMC article.
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.
Dite TA, Ling NXY, Scott JW, Hoque A, Galic S, Parker BL, Ngoei KRW, Langendorf CG, O'Brien MT, Kundu M, Viollet B, Steinberg GR, Sakamoto K, Kemp BE, Oakhill JS. Dite TA, et al. Among authors: sakamoto k. Nat Commun. 2017 Sep 18;8(1):571. doi: 10.1038/s41467-017-00628-y. Nat Commun. 2017. PMID: 28924239 Free PMC article.
4,788 results