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Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors.
Bioorg Med Chem. 2023 Jan 15;78:117132. doi: 10.1016/j.bmc.2022.117132. Epub 2022 Dec 16.
Bioorg Med Chem. 2023.
PMID: 36542960
Histamine H3 receptor and cholinesterases as synergistic targets for cognitive decline: Strategies to the rational design of multitarget ligands.
Lopes FB, Aranha CMSQ, Fernandes JPS.
Lopes FB, et al. Among authors: aranha cmsq.
Chem Biol Drug Des. 2021 Aug;98(2):212-225. doi: 10.1111/cbdd.13866. Epub 2021 Jun 21.
Chem Biol Drug Des. 2021.
PMID: 33991182
Review.
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Evaluation of the histamine H3 receptor antagonists from LINS01 series as cholinesterases inhibitors: Enzymatic and modeling studies.
Lopes FB, Aranha CMSQ, Corrêa MF, Fernandes GAB, Okamoto DN, Simões LPM, Junior NMN, Fernandes JPS.
Lopes FB, et al. Among authors: aranha cmsq.
Chem Biol Drug Des. 2022 Nov;100(5):722-729. doi: 10.1111/cbdd.14139. Epub 2022 Sep 8.
Chem Biol Drug Des. 2022.
PMID: 36050829
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