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Abacavir causes leukocyte/platelet crosstalk by activating neutrophil P2X7 receptors thus releasing soluble lectin-like oxidized low-density lipoprotein receptor-1.
Blanch-Ruíz MA, Sánchez-López A, Ríos-Navarro C, Ortega-Luna R, Collado-Díaz V, Orden S, Martínez-Cuesta MA, Esplugues JV, Álvarez Á. Blanch-Ruíz MA, et al. Among authors: martinez cuesta ma. Br J Pharmacol. 2023 Jun;180(11):1516-1532. doi: 10.1111/bph.16016. Epub 2023 Jan 18. Br J Pharmacol. 2023. PMID: 36541109 Free article.
Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?
Collado-Díaz V, Martinez-Cuesta MÁ, Blanch-Ruiz MA, Sánchez-López A, García-Martínez P, Peris JE, Usach I, Ivorra MD, Lacetera A, Martín-Santamaría S, Esplugues JV, Alvarez A. Collado-Díaz V, et al. Among authors: martinez cuesta ma. Front Pharmacol. 2021 Mar 31;12:613449. doi: 10.3389/fphar.2021.613449. eCollection 2021. Front Pharmacol. 2021. PMID: 33867979 Free PMC article.
Abacavir Induces Arterial Thrombosis in a Murine Model.
Collado-Diaz V, Andujar I, Sanchez-Lopez A, Orden S, Blanch-Ruiz MA, Martinez-Cuesta MA, Blas-García A, Esplugues JV, Álvarez Á. Collado-Diaz V, et al. Among authors: martinez cuesta ma. J Infect Dis. 2018 Jun 20;218(2):228-233. doi: 10.1093/infdis/jiy001. J Infect Dis. 2018. PMID: 29346575
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