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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J Med Chem. 2023 Jan 12;66(1):149-169. doi: 10.1021/acs.jmedchem.2c01658. Epub 2022 Dec 19.
J Med Chem. 2023.
PMID: 36533617
Free PMC article.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
Craig RA 2nd, Fox BM, Hu C, Lexa KW, Osipov M, Thottumkara AP, Larhammar M, Miyamoto T, Rana A, Kane LA, Yulyaningsih E, Solanoy H, Nguyen H, Chau R, Earr T, Kajiwara Y, Fleck D, Lucas A, Haddick PCG, Takahashi RH, Tong V, Wang J, Canet MJ, Poda SB, Scearce-Levie K, Srivastava A, Sweeney ZK, Xu M, Zhang R, He J, Lei Y, Zhuo Z, de Vicente J.
Craig RA 2nd, et al. Among authors: thottumkara ap.
J Med Chem. 2022 Dec 22;65(24):16290-16312. doi: 10.1021/acs.jmedchem.2c01056. Epub 2022 Dec 5.
J Med Chem. 2022.
PMID: 36469401
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SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
Miyamoto T, Kim C, Chow J, Dugas JC, DeGroot J, Bagdasarian AL, Thottumkara AP, Larhammar M, Calvert ME, Fox BM, Lewcock JW, Kane LA.
Miyamoto T, et al. Among authors: thottumkara ap.
J Biol Chem. 2024 Feb;300(2):105630. doi: 10.1016/j.jbc.2024.105630. Epub 2024 Jan 8.
J Biol Chem. 2024.
PMID: 38199568
Free PMC article.
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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N.
Lee BJ, et al. Among authors: thottumkara ap.
Nat Chem Biol. 2021 Nov;17(11):1209. doi: 10.1038/s41589-021-00905-4.
Nat Chem Biol. 2021.
PMID: 34616097
No abstract available.
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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N.
Lee BJ, et al. Among authors: thottumkara ap.
Nat Chem Biol. 2021 Aug;17(8):925. doi: 10.1038/s41589-021-00843-1.
Nat Chem Biol. 2021.
PMID: 34188221
No abstract available.
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Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N.
Lee BJ, et al. Among authors: thottumkara ap.
Nat Chem Biol. 2021 Oct;17(10):1065-1074. doi: 10.1038/s41589-021-00813-7. Epub 2021 Jun 24.
Nat Chem Biol. 2021.
PMID: 34168367
Free PMC article.
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Saxitoxin.
Thottumkara AP, Parsons WH, Du Bois J.
Thottumkara AP, et al.
Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5760-84. doi: 10.1002/anie.201308235. Epub 2014 Apr 25.
Angew Chem Int Ed Engl. 2014.
PMID: 24771635
Review.
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In situ generation of o-iodoxybenzoic acid (IBX) and the catalytic use of it in oxidation reactions in the presence of Oxone as a co-oxidant.
Thottumkara AP, Bowsher MS, Vinod TK.
Thottumkara AP, et al.
Org Lett. 2005 Jul 7;7(14):2933-6. doi: 10.1021/ol050875o.
Org Lett. 2005.
PMID: 15987173
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