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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J Med Chem. 2023 Jan 12;66(1):149-169. doi: 10.1021/acs.jmedchem.2c01658. Epub 2022 Dec 19.
J Med Chem. 2023.
PMID: 36533617
Free PMC article.
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders.
Ullman JC, Mellem KT, Xi Y, Ramanan V, Merritt H, Choy R, Gujral T, Young LEA, Blake K, Tep S, Homburger JR, O'Regan A, Ganesh S, Wong P, Satterfield TF, Lin B, Situ E, Yu C, Espanol B, Sarwaikar R, Fastman N, Tzitzilonis C, Lee P, Reiton D, Morton V, Santiago P, Won W, Powers H, Cummings BB, Hoek M, Graham RR, Chandriani SJ, Bainer R, DePaoli-Roach AA, Roach PJ, Hurley TD, Sun RC, Gentry MS, Sinz C, Dick RA, Noonberg SB, Beattie DT, Morgans DJ Jr, Green EM.
Ullman JC, et al. Among authors: mellem kt.
Sci Transl Med. 2024 Jan 17;16(730):eadf1691. doi: 10.1126/scitranslmed.adf1691. Epub 2024 Jan 17.
Sci Transl Med. 2024.
PMID: 38232139
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The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex.
Fastman NM, Liu Y, Ramanan V, Merritt H, Ambing E, DePaoli-Roach AA, Roach PJ, Hurley TD, Mellem KT, Ullman JC, Green E, Morgans D Jr, Tzitzilonis C.
Fastman NM, et al. Among authors: mellem kt.
Cell Rep. 2022 Jul 5;40(1):111041. doi: 10.1016/j.celrep.2022.111041.
Cell Rep. 2022.
PMID: 35793618
Free article.
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A simple, scalable synthetic route to (+)- and (-)-pseudoephenamine.
Mellem KT, Myers AG.
Mellem KT, et al.
Org Lett. 2013 Nov 1;15(21):5594-7. doi: 10.1021/ol402815d. Epub 2013 Oct 18.
Org Lett. 2013.
PMID: 24138164
Free PMC article.
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Synthesis of quaternary α-methyl α-amino acids by asymmetric alkylation of pseudoephenamine alaninamide pivaldimine.
Hugelshofer CL, Mellem KT, Myers AG.
Hugelshofer CL, et al. Among authors: mellem kt.
Org Lett. 2013 Jun 21;15(12):3134-7. doi: 10.1021/ol401337p. Epub 2013 Jun 7.
Org Lett. 2013.
PMID: 23746325
Free PMC article.
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Pseudoephenamine: a practical chiral auxiliary for asymmetric synthesis.
Morales MR, Mellem KT, Myers AG.
Morales MR, et al. Among authors: mellem kt.
Angew Chem Int Ed Engl. 2012 May 7;51(19):4568-71. doi: 10.1002/anie.201200370. Epub 2012 Mar 27.
Angew Chem Int Ed Engl. 2012.
PMID: 22461381
Free PMC article.
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