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Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling.
Sanderson DJ, Rodriguez KM, Bejan DS, Olafsen NE, Bohn ID, Kojic A, Sundalam S, Siordia IR, Duell AK, Deng N, Schultz C, Grant DM, Matthews J, Cohen MS. Sanderson DJ, et al. Among authors: bejan ds. Cell Chem Biol. 2023 Jan 19;30(1):43-54.e8. doi: 10.1016/j.chembiol.2022.11.012. Epub 2022 Dec 17. Cell Chem Biol. 2023. PMID: 36529140 Free PMC article.
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.
Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, Šileikytė J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS. Arnold MR, et al. Among authors: bejan ds. Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10. doi: 10.1016/j.chembiol.2022.11.006. Epub 2022 Dec 8. Cell Chem Biol. 2022. PMID: 36493759 Free article.
The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors.
Palve V, Knezevic CE, Bejan DS, Luo Y, Li X, Novakova S, Welsh EA, Fang B, Kinose F, Haura EB, Monteiro AN, Koomen JM, Cohen MS, Lawrence HR, Rix U. Palve V, et al. Among authors: bejan ds. Cell Chem Biol. 2022 Feb 17;29(2):202-214.e7. doi: 10.1016/j.chembiol.2021.07.008. Epub 2021 Jul 29. Cell Chem Biol. 2022. PMID: 34329582 Free PMC article.
Targeted Nanoparticle for Co-delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis.
Ngamcherdtrakul W, Bejan DS, Cruz-Muñoz W, Reda M, Zaidan HY, Siriwon N, Marshall S, Wang R, Nelson MA, Rehwaldt JPC, Gray JW, Hynynen K, Yantasee W. Ngamcherdtrakul W, et al. Among authors: bejan ds. Small. 2022 Mar;18(11):e2107550. doi: 10.1002/smll.202107550. Epub 2022 Jan 27. Small. 2022. PMID: 35083840 Free PMC article.
PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.
Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR. Parthasarathy S, et al. Among authors: bejan ds. bioRxiv [Preprint]. 2024 Apr 26:2024.04.26.591186. doi: 10.1101/2024.04.26.591186. bioRxiv. 2024. PMID: 38712082 Free PMC article. Preprint.
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