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Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAFV600E with promising antiproliferative properties.
Arch Pharm (Weinheim). 2023 Apr;356(4):e2200464. doi: 10.1002/ardp.202200464. Epub 2022 Dec 16.
Arch Pharm (Weinheim). 2023.
PMID: 36526595
EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules.
Abou-Zied HA, Youssif BGM, Mohamed MFA, Hayallah AM, Abdel-Aziz M.
Abou-Zied HA, et al.
Bioorg Chem. 2019 Aug;89:102997. doi: 10.1016/j.bioorg.2019.102997. Epub 2019 May 22.
Bioorg Chem. 2019.
PMID: 31136902
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Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis-Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors.
Al-Wahaibi LH, Abou-Zied HA, Beshr EAM, Youssif BGM, Hayallah AM, Abdel-Aziz M.
Al-Wahaibi LH, et al. Among authors: abou zied ha.
Int J Mol Sci. 2023 May 22;24(10):9104. doi: 10.3390/ijms24109104.
Int J Mol Sci. 2023.
PMID: 37240450
Free PMC article.
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Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAFV600E Inhibitory Pathways.
Al-Wahaibi LH, Abou-Zied HA, Hisham M, Beshr EAM, Youssif BGM, Bräse S, Hayallah AM, Abdel-Aziz M.
Al-Wahaibi LH, et al. Among authors: abou zied ha.
Molecules. 2023 Sep 12;28(18):6586. doi: 10.3390/molecules28186586.
Molecules. 2023.
PMID: 37764362
Free PMC article.
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Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAFV600E: Design, Synthesis, and Antiproliferative Activity.
Al-Wahaibi LH, Hisham M, Abou-Zied HA, Hassan HA, Youssif BGM, Bräse S, Hayallah AM, Abdel-Aziz M.
Al-Wahaibi LH, et al. Among authors: abou zied ha.
Pharmaceuticals (Basel). 2023 Oct 26;16(11):1522. doi: 10.3390/ph16111522.
Pharmaceuticals (Basel). 2023.
PMID: 38004388
Free PMC article.
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New pyrrolidine-carboxamide derivatives as dual antiproliferative EGFR/CDK2 inhibitors.
Frejat FOA, Zhao B, Furaijit N, Wang L, Abou-Zied HA, Fathy HM, Mohamed FAM, Youssif BGM, Wu C.
Frejat FOA, et al. Among authors: abou zied ha.
Chem Biol Drug Des. 2024 Jan;103(1):e14422. doi: 10.1111/cbdd.14422.
Chem Biol Drug Des. 2024.
PMID: 38230772
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