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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Chavarria-Smith J, Chiu CPC, Jackman JK, Yin J, Zhang J, Hackney JA, Lin WY, Tyagi T, Sun Y, Tao J, Dunlap D, Morton WD, Ghodge SV, Maun HR, Li H, Hernandez-Barry H, Loyet KM, Chen E, Liu J, Tam C, Yaspan BL, Cai H, Balazs M, Arron JR, Li J, Wittwer AJ, Pappu R, Austin CD, Lee WP, Lazarus RA, Sudhamsu J, Koerber JT, Yi T. Chavarria-Smith J, et al. Sci Transl Med. 2022 Dec 14;14(675):eabp9159. doi: 10.1126/scitranslmed.abp9159. Epub 2022 Dec 14. Sci Transl Med. 2022. PMID: 36516271
IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
Cox CB, Storm EE, Kapoor VN, Chavarria-Smith J, Lin DL, Wang L, Li Y, Kljavin N, Ota N, Bainbridge TW, Anderson K, Roose-Girma M, Warming S, Arron JR, Turley SJ, de Sauvage FJ, van Lookeren Campagne M. Cox CB, et al. Among authors: chavarria smith j. Sci Immunol. 2021 May 7;6(59):eabe8856. doi: 10.1126/sciimmunol.abe8856. Sci Immunol. 2021. PMID: 33963061
Humoral immunity goes hormonal.
Chavarria-Smith J, Hazenbos WLW, van Lookeren Campagne M. Chavarria-Smith J, et al. Nat Immunol. 2018 Oct;19(10):1044-1046. doi: 10.1038/s41590-018-0216-x. Nat Immunol. 2018. PMID: 30232411 No abstract available.
The NLRP1 inflammasomes.
Chavarría-Smith J, Vance RE. Chavarría-Smith J, et al. Immunol Rev. 2015 May;265(1):22-34. doi: 10.1111/imr.12283. Immunol Rev. 2015. PMID: 25879281 Review.
NLRP1 is an inflammasome sensor for Toxoplasma gondii.
Ewald SE, Chavarria-Smith J, Boothroyd JC. Ewald SE, et al. Among authors: chavarria smith j. Infect Immun. 2014 Jan;82(1):460-8. doi: 10.1128/IAI.01170-13. Epub 2013 Nov 11. Infect Immun. 2014. PMID: 24218483 Free PMC article.
Recognition of bacteria by inflammasomes.
von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE. von Moltke J, et al. Among authors: chavarria smith j. Annu Rev Immunol. 2013;31:73-106. doi: 10.1146/annurev-immunol-032712-095944. Epub 2012 Nov 26. Annu Rev Immunol. 2013. PMID: 23215645 Review.