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A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8.
Tarasov KV, Chakir K, Riordon DR, Lyashkov AE, Ahmet I, Perino MG, Silvester AJ, Zhang J, Wang M, Lukyanenko YO, Qu JH, Barrera MC, Juhaszova M, Tarasova YS, Ziman B, Telljohann R, Kumar V, Ranek M, Lammons J, Bychkov R, de Cabo R, Jun S, Keceli G, Gupta A, Yang D, Aon MA, Adamo L, Morrell CH, Otu W, Carroll C, Chambers S, Paolocci N, Huynh T, Pacak K, Weiss R, Field L, Sollott SJ, Lakatta EG. Tarasov KV, et al. Among authors: lyashkov ae. Elife. 2022 Dec 14;11:e80949. doi: 10.7554/eLife.80949. Elife. 2022. PMID: 36515265 Free PMC article.
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.
Vinogradova TM, Lyashkov AE, Zhu W, Ruknudin AM, Sirenko S, Yang D, Deo S, Barlow M, Johnson S, Caffrey JL, Zhou YY, Xiao RP, Cheng H, Stern MD, Maltsev VA, Lakatta EG. Vinogradova TM, et al. Among authors: lyashkov ae. Circ Res. 2006 Mar 3;98(4):505-14. doi: 10.1161/01.RES.0000204575.94040.d1. Epub 2006 Jan 19. Circ Res. 2006. PMID: 16424365
Membrane potential fluctuations resulting from submembrane Ca2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state.
Bogdanov KY, Maltsev VA, Vinogradova TM, Lyashkov AE, Spurgeon HA, Stern MD, Lakatta EG. Bogdanov KY, et al. Among authors: lyashkov ae. Circ Res. 2006 Oct 27;99(9):979-87. doi: 10.1161/01.RES.0000247933.66532.0b. Epub 2006 Sep 28. Circ Res. 2006. PMID: 17008599
Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells.
Younes A, Lyashkov AE, Graham D, Sheydina A, Volkova MV, Mitsak M, Vinogradova TM, Lukyanenko YO, Li Y, Ruknudin AM, Boheler KR, van Eyk J, Lakatta EG. Younes A, et al. Among authors: lyashkov ae. J Biol Chem. 2008 May 23;283(21):14461-8. doi: 10.1074/jbc.M707540200. Epub 2008 Mar 20. J Biol Chem. 2008. PMID: 18356168 Free PMC article.
Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
Lyashkov AE, Vinogradova TM, Zahanich I, Li Y, Younes A, Nuss HB, Spurgeon HA, Maltsev VA, Lakatta EG. Lyashkov AE, et al. Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H949-59. doi: 10.1152/ajpheart.01340.2008. Epub 2009 Jun 19. Am J Physiol Heart Circ Physiol. 2009. PMID: 19542482 Free PMC article.
42 results