Franco A - Search Results

1

Mitochondrial Dysfunction and Pharmacodynamics of Mitofusin Activation in Murine Charcot-Marie-Tooth Disease Type 2A.

Franco A, Dang X, Zhang L, Molinoff PB, Dorn GW 2nd. Franco A, et al. J Pharmacol Exp Ther. 2022 Nov;383(2):137-148. doi: 10.1124/jpet.122.001332. Epub 2022 Sep 2. J Pharmacol Exp Ther. 2022. PMID: 36507849 Free PMC article.

2

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.

Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW 2nd, Trimarco B, Iaccarino G. Ciccarelli M, et al. Among authors: franco a. Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2415-24. doi: 10.1161/ATVBAHA.113.302262. Epub 2013 Aug 15. Arterioscler Thromb Vasc Biol. 2013. PMID: 23950144 Free PMC article.

3

Correcting mitochondrial fusion by manipulating mitofusin conformations.

Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II. Franco A, et al. Nature. 2016 Dec 1;540(7631):74-79. doi: 10.1038/nature20156. Epub 2016 Oct 24. Nature. 2016. PMID: 27775718 Free PMC article.

4

Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence.

Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Song M, et al. Among authors: franco a. Cell Metab. 2017 Dec 5;26(6):872-883.e5. doi: 10.1016/j.cmet.2017.09.023. Epub 2017 Oct 26. Cell Metab. 2017. PMID: 29107503 Free PMC article.

5

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.

Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW 2nd. Rocha AG, et al. Among authors: franco a. Science. 2018 Apr 20;360(6386):336-341. doi: 10.1126/science.aao1785. Science. 2018. PMID: 29674596 Free PMC article.

6

G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.

Franco A, Zhang L, Matkovich SJ, Kovacs A, Dorn GW 2nd. Franco A, et al. J Mol Cell Cardiol. 2018 Aug;121:60-68. doi: 10.1016/j.yjmcc.2018.06.009. Epub 2018 Jun 30. J Mol Cell Cardiol. 2018. PMID: 29969579 Free PMC article.

7

Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model.

Zhou Y, Carmona S, Muhammad AKMG, Bell S, Landeros J, Vazquez M, Ho R, Franco A, Lu B, Dorn GW 2nd, Wang S, Lutz CM, Baloh RH. Zhou Y, et al. Among authors: franco a. J Clin Invest. 2019 Mar 18;129(4):1756-1771. doi: 10.1172/JCI124194. eCollection 2019 Mar 18. J Clin Invest. 2019. PMID: 30882371 Free PMC article.

8

The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca²⁺-NFATc1 axis.

Ballard A, Zeng R, Zarei A, Shao C, Cox L, Yan H, Franco A, Dorn GW 2nd, Faccio R, Veis DJ. Ballard A, et al. Among authors: franco a. J Biol Chem. 2020 May 8;295(19):6629-6640. doi: 10.1074/jbc.RA119.012023. Epub 2020 Mar 12. J Biol Chem. 2020. PMID: 32165499 Free PMC article.

9

Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases.

Dang X, Zhang L, Franco A, Li J, Rocha AG, Devanathan S, Dolle RE, Bernstein PR, Dorn GW 2nd. Dang X, et al. Among authors: franco a. J Med Chem. 2020 Jul 9;63(13):7033-7051. doi: 10.1021/acs.jmedchem.0c00366. Epub 2020 Jun 18. J Med Chem. 2020. PMID: 32506913 Free PMC article.

10

Correction to "Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases".

Dang X, Zhang L, Franco A, Li J, Rocha AG, Devanathan S, Dolle RE, Bernstein PR, Dorn GW 2nd. Dang X, et al. Among authors: franco a. J Med Chem. 2020 Sep 10;63(17):10086. doi: 10.1021/acs.jmedchem.0c01267. Epub 2020 Aug 21. J Med Chem. 2020. PMID: 32822172 No abstract available.

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