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Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.
Moreno-Càceres J, Caja L, Mainez J, Mayoral R, Martín-Sanz P, Moreno-Vicente R, Del Pozo MÁ, Dooley S, Egea G, Fabregat I. Moreno-Càceres J, et al. Among authors: caja l. Cell Death Dis. 2014 Jul 17;5(7):e1326. doi: 10.1038/cddis.2014.294. Cell Death Dis. 2014. PMID: 25032849 Free PMC article.
A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins.
Pérez-Perarnau A, Preciado S, Palmeri CM, Moncunill-Massaguer C, Iglesias-Serret D, González-Gironès DM, Miguel M, Karasawa S, Sakamoto S, Cosialls AM, Rubio-Patiño C, Saura-Esteller J, Ramón R, Caja L, Fabregat I, Pons G, Handa H, Albericio F, Gil J, Lavilla R. Pérez-Perarnau A, et al. Among authors: caja l. Angew Chem Int Ed Engl. 2014 Sep 15;53(38):10150-4. doi: 10.1002/anie.201405758. Epub 2014 Sep 5. Angew Chem Int Ed Engl. 2014. PMID: 25196378
The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.
Sancho P, Bertran E, Caja L, Carmona-Cuenca I, Murillo MM, Fabregat I. Sancho P, et al. Among authors: caja l. Biochim Biophys Acta. 2009 Feb;1793(2):253-63. doi: 10.1016/j.bbamcr.2008.09.003. Epub 2008 Sep 24. Biochim Biophys Acta. 2009. PMID: 18848961 Free article.
40 results