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Tuberculosis treatment failure associated with evolution of antibiotic resilience.
Liu Q, Zhu J, Dulberger CL, Stanley S, Wilson S, Chung ES, Wang X, Culviner P, Liu YJ, Hicks ND, Babunovic GH, Giffen SR, Aldridge BB, Garner EC, Rubin EJ, Chao MC, Fortune SM. Liu Q, et al. Among authors: wang x. Science. 2022 Dec 9;378(6624):1111-1118. doi: 10.1126/science.abq2787. Epub 2022 Dec 8. Science. 2022. PMID: 36480634 Free PMC article.
Morphological profiling of tubercle bacilli identifies drug pathways of action.
Smith TC 2nd, Pullen KM, Olson MC, McNellis ME, Richardson I, Hu S, Larkins-Ford J, Wang X, Freundlich JS, Ando DM, Aldridge BB. Smith TC 2nd, et al. Among authors: wang x. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18744-18753. doi: 10.1073/pnas.2002738117. Epub 2020 Jul 17. Proc Natl Acad Sci U S A. 2020. PMID: 32680963 Free PMC article.
Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design.
Rudraraju RS, Daher SS, Gallardo-Macias R, Wang X, Neiditch MB, Freundlich JS. Rudraraju RS, et al. Among authors: wang x. Front Cell Infect Microbiol. 2022 Sep 15;12:1008213. doi: 10.3389/fcimb.2022.1008213. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36189349 Free PMC article. Review.
A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.
Inoyama D, Awasthi D, Capodagli GC, Tsotetsi K, Sukheja P, Zimmerman M, Li SG, Jadhav R, Russo R, Wang X, Grady C, Richmann T, Shrestha R, Li L, Ahn YM, Ho Liang HP, Mina M, Park S, Perlin DS, Connell N, Dartois V, Alland D, Neiditch MB, Kumar P, Freundlich JS. Inoyama D, et al. Among authors: wang x. Cell Chem Biol. 2020 May 21;27(5):560-570.e10. doi: 10.1016/j.chembiol.2020.02.007. Epub 2020 Mar 19. Cell Chem Biol. 2020. PMID: 32197094 Free PMC article.
Antitubercular Triazines: Optimization and Intrabacterial Metabolism.
Wang X, Inoyama D, Russo R, Li SG, Jadhav R, Stratton TP, Mittal N, Bilotta JA, Singleton E, Kim T, Paget SD, Pottorf RS, Ahn YM, Davila-Pagan A, Kandasamy S, Grady C, Hussain S, Soteropoulos P, Zimmerman MD, Ho HP, Park S, Dartois V, Ekins S, Connell N, Kumar P, Freundlich JS. Wang X, et al. Cell Chem Biol. 2020 Feb 20;27(2):172-185.e11. doi: 10.1016/j.chembiol.2019.10.010. Epub 2019 Nov 8. Cell Chem Biol. 2020. PMID: 31711854 Free PMC article.
Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis.
Stec J, Vilchèze C, Lun S, Perryman AL, Wang X, Freundlich JS, Bishai W, Jacobs WR Jr, Kozikowski AP. Stec J, et al. Among authors: wang x. ChemMedChem. 2014 Nov;9(11):2528-37. doi: 10.1002/cmdc.201402255. Epub 2014 Aug 27. ChemMedChem. 2014. PMID: 25165007 Free PMC article.
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