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Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria.
Grinter R, Ney B, Brammananth R, Barlow CK, Cordero PRF, Gillett DL, Izoré T, Cryle MJ, Harold LK, Cook GM, Taiaroa G, Williamson DA, Warden AC, Oakeshott JG, Taylor MC, Crellin PK, Jackson CJ, Schittenhelm RB, Coppel RL, Greening C. Grinter R, et al. Among authors: harold lk. mSystems. 2020 May 19;5(3):e00389-20. doi: 10.1128/mSystems.00389-20. mSystems. 2020. PMID: 32430409 Free PMC article.
A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis.
Adolph C, Cheung CY, McNeil MB, Jowsey WJ, Williams ZC, Hards K, Harold LK, Aboelela A, Bujaroski RS, Buckley BJ, Tyndall JDA, Li Z, Langer JD, Preiss L, Meier T, Steyn AJC, Rhee KY, Berney M, Kelso MJ, Cook GM. Adolph C, et al. Among authors: harold lk. Cell Chem Biol. 2024 Apr 18;31(4):683-698.e7. doi: 10.1016/j.chembiol.2023.12.002. Epub 2023 Dec 26. Cell Chem Biol. 2024. PMID: 38151019
An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.
Hards K, Cheung CY, Waller N, Adolph C, Keighley L, Tee ZS, Harold LK, Menorca A, Bujaroski RS, Buckley BJ, Tyndall JDA, McNeil MB, Rhee KY, Opel-Reading HK, Krause K, Preiss L, Langer JD, Meier T, Hasenoehrl EJ, Berney M, Kelso MJ, Cook GM. Hards K, et al. Among authors: harold lk. Commun Biol. 2022 Feb 24;5(1):166. doi: 10.1038/s42003-022-03110-8. Commun Biol. 2022. PMID: 35210534 Free PMC article.
An epigenetic switch activates bacterial quorum sensing and horizontal transfer of an integrative and conjugative element.
Ramsay JP, Bastholm TR, Verdonk CJ, Tambalo DD, Sullivan JT, Harold LK, Panganiban BA, Colombi E, Perry BJ, Jowsey W, Morris C, Hynes MF, Bond CS, Cameron ADS, Yost CK, Ronson CW. Ramsay JP, et al. Among authors: harold lk. Nucleic Acids Res. 2022 Jan 25;50(2):975-988. doi: 10.1093/nar/gkab1217. Nucleic Acids Res. 2022. PMID: 34904658 Free PMC article.
14 results