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Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo.
Torchia JA, Tavares AH, Carstensen LS, Chen DY, Huang J, Xiao T, Mukherjee S, Reeves PM, Tu H, Sluder AE, Chen B, Kotton DN, Bowen RA, Saeed M, Poznansky MC, Freeman GJ. Torchia JA, et al. Among authors: freeman gj. Sci Adv. 2022 Dec 9;8(49):eabq6527. doi: 10.1126/sciadv.abq6527. Epub 2022 Dec 7. Sci Adv. 2022. PMID: 36475798 Free PMC article.
Emerging concepts in PD-1 checkpoint biology.
Pauken KE, Torchia JA, Chaudhri A, Sharpe AH, Freeman GJ. Pauken KE, et al. Among authors: freeman gj. Semin Immunol. 2021 Feb;52:101480. doi: 10.1016/j.smim.2021.101480. Epub 2021 May 15. Semin Immunol. 2021. PMID: 34006473 Free PMC article. Review.
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Ricklefs FL, Alayo Q, Krenzlin H, Mahmoud AB, Speranza MC, Nakashima H, Hayes JL, Lee K, Balaj L, Passaro C, Rooj AK, Krasemann S, Carter BS, Chen CC, Steed T, Treiber J, Rodig S, Yang K, Nakano I, Lee H, Weissleder R, Breakefield XO, Godlewski J, Westphal M, Lamszus K, Freeman GJ, Bronisz A, Lawler SE, Chiocca EA. Ricklefs FL, et al. Among authors: freeman gj. Sci Adv. 2018 Mar 7;4(3):eaar2766. doi: 10.1126/sciadv.aar2766. eCollection 2018 Mar. Sci Adv. 2018. PMID: 29532035 Free PMC article.
Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non-small cell lung cancer.
Huang Q, Li F, Hu H, Fang Z, Gao Z, Xia G, Ng WL, Khodadadi-Jamayran A, Chen T, Deng J, Zhang H, Almonte C, Labbe K, Han H, Geng K, Tang S, Freeman GJ, Li Y, Chen H, Wong KK. Huang Q, et al. Among authors: freeman gj. Sci Adv. 2022 Feb 4;8(5):eabi9533. doi: 10.1126/sciadv.abi9533. Epub 2022 Feb 4. Sci Adv. 2022. PMID: 35119931 Free PMC article.
A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.
Kim HY, Eyheramonho MB, Pichavant M, Gonzalez Cambaceres C, Matangkasombut P, Cervio G, Kuperman S, Moreiro R, Konduru K, Manangeeswaran M, Freeman GJ, Kaplan GG, DeKruyff RH, Umetsu DT, Rosenzweig SD. Kim HY, et al. Among authors: freeman gj. J Clin Invest. 2011 Mar;121(3):1111-8. doi: 10.1172/JCI44182. Epub 2011 Feb 21. J Clin Invest. 2011. PMID: 21339644 Free PMC article.
A Comparison of Murine PD-1 and PD-L1 Monoclonal Antibodies.
Bu MT, Yuan L, Klee AN, Freeman GJ. Bu MT, et al. Among authors: freeman gj. Monoclon Antib Immunodiagn Immunother. 2022 Aug;41(4):202-209. doi: 10.1089/mab.2021.0068. Epub 2022 Aug 4. Monoclon Antib Immunodiagn Immunother. 2022. PMID: 35925787 Free PMC article.
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques.
Kauffman KD, Sakai S, Lora NE, Namasivayam S, Baker PJ, Kamenyeva O, Foreman TW, Nelson CE, Oliveira-de-Souza D, Vinhaes CL, Yaniv Z, Lindestam Arleham CS, Sette A, Freeman GJ, Moore R; NIAID/DIR Tuberculosis Imaging Program; Sher A, Mayer-Barber KD, Andrade BB, Kabat J, Via LE, Barber DL. Kauffman KD, et al. Among authors: freeman gj. Sci Immunol. 2021 Jan 15;6(55):eabf3861. doi: 10.1126/sciimmunol.abf3861. Sci Immunol. 2021. PMID: 33452107 Free PMC article.
Role of PD-1 during effector CD8 T cell differentiation.
Ahn E, Araki K, Hashimoto M, Li W, Riley JL, Cheung J, Sharpe AH, Freeman GJ, Irving BA, Ahmed R. Ahn E, et al. Among authors: freeman gj. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4749-4754. doi: 10.1073/pnas.1718217115. Epub 2018 Apr 13. Proc Natl Acad Sci U S A. 2018. PMID: 29654146 Free PMC article.
443 results