Ludwig R - Search Results

1

Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis.

McClain A, Zhang Y, Yin Y, Wang Q, Hwang LY, Gu Y, Beckman J, Ludwig R. McClain A, et al. Among authors: ludwig r. Anal Chem. 2022 Dec 20;94(50):17388-17395. doi: 10.1021/acs.analchem.2c02630. Epub 2022 Dec 6. Anal Chem. 2022. PMID: 36472948 Free PMC article.

2

Enhancing Host-Cell Protein Detection in Protein Therapeutics Using HILIC Enrichment and Proteomic Analysis.

Wang Q, Slaney TR, Wu W, Ludwig R, Tao L, Leone A. Wang Q, et al. Among authors: ludwig r. Anal Chem. 2020 Aug 4;92(15):10327-10335. doi: 10.1021/acs.analchem.0c00360. Epub 2020 Jul 17. Anal Chem. 2020. PMID: 32614163

3

Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.

Jiang T, Song H, Slaney TR, Wu W, Langsdorf E, Gupta G, Ludwig R, Tao L, McVey D, Das TK. Jiang T, et al. Among authors: ludwig r. Anal Chem. 2017 Dec 5;89(23):12749-12755. doi: 10.1021/acs.analchem.7b02914. Epub 2017 Nov 14. Anal Chem. 2017. PMID: 29086552

4

Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry.

Yan Y, Wei H, Fu Y, Jusuf S, Zeng M, Ludwig R, Krystek SR Jr, Chen G, Tao L, Das TK. Yan Y, et al. Among authors: ludwig r. Anal Chem. 2016 Feb 16;88(4):2041-50. doi: 10.1021/acs.analchem.5b02800. Epub 2016 Jan 29. Anal Chem. 2016. PMID: 26824491

5

Identification and quantification of signal peptide variants in an IgG1 monoclonal antibody produced in mammalian cell lines.

Huang Y, Fu J, Ludwig R, Tao L, Bongers J, Ma L, Yao M, Zhu M, Das T, Russell R. Huang Y, et al. Among authors: ludwig r. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:193-200. doi: 10.1016/j.jchromb.2017.08.046. Epub 2017 Oct 12. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 29078145

6

Subunit mass analysis for monitoring multiple attributes of monoclonal antibodies.

Liu P, Zhu X, Wu W, Ludwig R, Song H, Li R, Zhou J, Tao L, Leone AM. Liu P, et al. Among authors: ludwig r. Rapid Commun Mass Spectrom. 2019 Jan 15;33(1):31-40. doi: 10.1002/rcm.8301. Rapid Commun Mass Spectrom. 2019. PMID: 30286260

7

Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process.

Du C, Huang Y, Borwankar A, Tan Z, Cura A, Yee JC, Singh N, Ludwig R, Borys M, Ghose S, Mussa N, Li ZJ. Du C, et al. Among authors: ludwig r. MAbs. 2018 Apr;10(3):500-510. doi: 10.1080/19420862.2018.1424609. Epub 2018 Jan 23. MAbs. 2018. PMID: 29336721 Free PMC article.

8

Characterization and identification of alanine to serine sequence variants in an IgG4 monoclonal antibody produced in mammalian cell lines.

Fu J, Bongers J, Tao L, Huang D, Ludwig R, Huang Y, Qian Y, Basch J, Goldstein J, Krishnan R, You L, Li ZJ, Russell RJ. Fu J, et al. Among authors: ludwig r. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:1-8. doi: 10.1016/j.jchromb.2012.09.023. Epub 2012 Sep 26. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 23122394

9

Structure-Function Assessment and High-Throughput Quantification of Site-Specific Aspartate Isomerization in Monoclonal Antibody Using a Novel Analytical Tool Kit.

Zhou K, Cao X, Bautista J, Chen Z, Hershey N, Ludwig R, Tao L, Zeng M, Das TK. Zhou K, et al. Among authors: ludwig r. J Pharm Sci. 2020 Jan;109(1):422-428. doi: 10.1016/j.xphs.2019.08.018. Epub 2019 Aug 27. J Pharm Sci. 2020. PMID: 31469998

10

Vitamin B₁₂ association with mAbs: Mechanism and potential mitigation strategies.

Du C, Martin R, Huang Y, Borwankar A, Tan Z, West J, Singh N, Borys M, Ghose S, Ludwig R, Tao L, Li ZJ. Du C, et al. Among authors: ludwig r. Biotechnol Bioeng. 2018 Apr;115(4):900-909. doi: 10.1002/bit.26511. Epub 2017 Dec 19. Biotechnol Bioeng. 2018. PMID: 29205285

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