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Sphingosine 1-phosphate has a negative effect on RBC storage quality.
Hay A, Nemkov T, Gamboni F, Dzieciatkowska M, Key A, Galbraith M, Bartsch K, Sun K, Xia Y, Stone M, Busch MP, Norris PJ, Zimring JC, D'Alessandro A. Hay A, et al. Among authors: sun k. Blood Adv. 2023 Apr 25;7(8):1379-1393. doi: 10.1182/bloodadvances.2022008936. Blood Adv. 2023. PMID: 36469038 Free PMC article.
Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.
Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ, Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A, Kriebardis A, Antonelou M, Papassideri I, Young CT, Thomas TA, Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA, D'Alessandro A. Nemkov T, et al. Among authors: sun k. Haematologica. 2018 Feb;103(2):361-372. doi: 10.3324/haematol.2017.178608. Epub 2017 Oct 27. Haematologica. 2018. PMID: 29079593 Free PMC article.
AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia.
D'Alessandro A, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC. D'Alessandro A, et al. Among authors: sun k. J Proteome Res. 2016 Oct 7;15(10):3883-3895. doi: 10.1021/acs.jproteome.6b00733. Epub 2016 Sep 27. J Proteome Res. 2016. PMID: 27646145 Free PMC article.
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia.
Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y. Sun K, et al. Nat Commun. 2016 Jul 15;7:12086. doi: 10.1038/ncomms12086. Nat Commun. 2016. PMID: 27417539 Free PMC article.
Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y. Sun K, et al. Sci Rep. 2017 Nov 10;7(1):15281. doi: 10.1038/s41598-017-13667-8. Sci Rep. 2017. PMID: 29127281 Free PMC article.
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.
Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y. Song A, et al. Among authors: sun k. Nat Commun. 2017 Feb 7;8:14108. doi: 10.1038/ncomms14108. Nat Commun. 2017. PMID: 28169986 Free PMC article.
6,954 results