Saleh MAA - Search Results

1

The PBPK LeiCNS-PK3.0 framework predicts Nirmatrelvir (but not Remdesivir or Molnupiravir) to achieve effective concentrations against SARS-CoV-2 in human brain cells.

Saleh MAA, Hirasawa M, Sun M, Gülave B, Elassaiss-Schaap J, de Lange ECM. Saleh MAA, et al. Eur J Pharm Sci. 2023 Feb 1;181:106345. doi: 10.1016/j.ejps.2022.106345. Epub 2022 Nov 30. Eur J Pharm Sci. 2023. PMID: 36462547 Free PMC article.

2

Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A "WHAT-IF" Simulation Study.

Saleh MAA, de Lange ECM. Saleh MAA, et al. Pharmaceutics. 2021 Jan 13;13(1):95. doi: 10.3390/pharmaceutics13010095. Pharmaceutics. 2021. PMID: 33451111 Free PMC article.

3

Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations.

Saleh MAA, Loo CF, Elassaiss-Schaap J, De Lange ECM. Saleh MAA, et al. J Pharmacokinet Pharmacodyn. 2021 Oct;48(5):725-741. doi: 10.1007/s10928-021-09768-7. Epub 2021 Jun 17. J Pharmacokinet Pharmacodyn. 2021. PMID: 34142308 Free PMC article.

4

The Extension of the LeiCNS-PK3.0 Model in Combination with the "Handshake" Approach to Understand Brain Tumor Pathophysiology.

Hirasawa M, Saleh MAA, de Lange ECM. Hirasawa M, et al. Among authors: saleh maa. Pharm Res. 2022 Jul;39(7):1343-1361. doi: 10.1007/s11095-021-03154-1. Epub 2022 Mar 7. Pharm Res. 2022. PMID: 35258766 Free PMC article.

5

Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC₅₀ Values in Aging and Alzheimer's Disease, Using the Physiologically Based LeiCNS-PK3.0 Model.

Saleh MAA, Bloemberg JS, Elassaiss-Schaap J, de Lange ECM. Saleh MAA, et al. Pharm Res. 2022 Jul;39(7):1303-1319. doi: 10.1007/s11095-022-03281-3. Epub 2022 May 23. Pharm Res. 2022. PMID: 35606598 Free PMC article.

6

Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice.

Saleh MAA, Gülave B, Campagne O, Stewart CF, Elassaiss-Schaap J, de Lange ECM. Saleh MAA, et al. Pharm Res. 2023 Nov;40(11):2555-2566. doi: 10.1007/s11095-023-03554-5. Epub 2023 Jul 13. Pharm Res. 2023. PMID: 37442882 Free PMC article.

7

Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations.

Aulin LBS, Tandar ST, van Zijp T, van Ballegooie E, van der Graaf PH, Saleh MAA, Välitalo P, van Hasselt JGC. Aulin LBS, et al. Among authors: saleh maa. Clin Pharmacokinet. 2022 Dec;61(12):1735-1748. doi: 10.1007/s40262-022-01186-3. Epub 2022 Nov 19. Clin Pharmacokinet. 2022. PMID: 36401151 Free PMC article.

8

Host-response biomarkers for the diagnosis of bacterial respiratory tract infections.

Saleh MAA, van de Garde EMW, van Hasselt JGC. Saleh MAA, et al. Clin Chem Lab Med. 2019 Mar 26;57(4):442-451. doi: 10.1515/cclm-2018-0682. Clin Chem Lab Med. 2019. PMID: 30183665 Free article. Review.

9

Biomarker-Guided Individualization of Antibiotic Therapy.

Aulin LBS, de Lange DW, Saleh MAA, van der Graaf PH, Völler S, van Hasselt JGC. Aulin LBS, et al. Among authors: saleh maa. Clin Pharmacol Ther. 2021 Aug;110(2):346-360. doi: 10.1002/cpt.2194. Epub 2021 Mar 2. Clin Pharmacol Ther. 2021. PMID: 33559152 Free PMC article. Review.

10

Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Gülave B, Budda D, Saleh MAA, van Hasselt JGC, de Lange ECM. Gülave B, et al. Among authors: saleh maa. Eur J Pharm Sci. 2023 Aug 1;187:106482. doi: 10.1016/j.ejps.2023.106482. Epub 2023 May 27. Eur J Pharm Sci. 2023. PMID: 37247795 Free article.

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