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The PBPK LeiCNS-PK3.0 framework predicts Nirmatrelvir (but not Remdesivir or Molnupiravir) to achieve effective concentrations against SARS-CoV-2 in human brain cells.
Eur J Pharm Sci. 2023 Feb 1;181:106345. doi: 10.1016/j.ejps.2022.106345. Epub 2022 Nov 30.
Eur J Pharm Sci. 2023.
PMID: 36462547
Free PMC article.
Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?
Gülave B, Budda D, Saleh MAA, van Hasselt JGC, de Lange ECM.
Gülave B, et al.
Eur J Pharm Sci. 2023 Aug 1;187:106482. doi: 10.1016/j.ejps.2023.106482. Epub 2023 May 27.
Eur J Pharm Sci. 2023.
PMID: 37247795
Free article.
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Revealing the Neuroendocrine Response After Remoxipride Treatment Using Multi-Biomarker Discovery and Quantifying It by PK/PD Modeling.
van den Brink WJ, Wong YC, Gülave B, van der Graaf PH, de Lange EC.
van den Brink WJ, et al. Among authors: gulave b.
AAPS J. 2017 Jan;19(1):274-285. doi: 10.1208/s12248-016-0002-3. Epub 2016 Oct 26.
AAPS J. 2017.
PMID: 27785749
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Non-linear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix.
Budda D, Gülave B, van Hasselt JGC, de Lange ECM.
Budda D, et al. Among authors: gulave b.
Br J Pharmacol. 2024 Apr 25. doi: 10.1111/bph.16394. Online ahead of print.
Br J Pharmacol. 2024.
PMID: 38663441
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Corrigendum to "Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?" [European Journal of Pharmaceutical Sciences 187 (2023) 106482].
Gülave B, Budda D, Saleh MA, van Hasselt JC, de Lange EC.
Gülave B, et al.
Eur J Pharm Sci. 2024 May 1;196:106736. doi: 10.1016/j.ejps.2024.106736. Epub 2024 Mar 15.
Eur J Pharm Sci. 2024.
PMID: 38490876
Free article.
No abstract available.
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Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice.
Saleh MAA, Gülave B, Campagne O, Stewart CF, Elassaiss-Schaap J, de Lange ECM.
Saleh MAA, et al. Among authors: gulave b.
Pharm Res. 2023 Nov;40(11):2555-2566. doi: 10.1007/s11095-023-03554-5. Epub 2023 Jul 13.
Pharm Res. 2023.
PMID: 37442882
Free PMC article.
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High body mass index and pre-existing autoimmune disease are associated with an increased risk of immune-related adverse events in cancer patients treated with PD-(L)1 inhibitors across different solid tumors.
Gülave B, Hew MN, de Groot JS, Rodwell L, Teerenstra S, Fabriek BO.
Gülave B, et al.
ESMO Open. 2021 Jun;6(3):100107. doi: 10.1016/j.esmoop.2021.100107. Epub 2021 Apr 20.
ESMO Open. 2021.
PMID: 33887689
Free PMC article.
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