How Do Branched Detergents Stabilize GPCRs in Micelles?
Lee S, Ghosh S, Jana S, Robertson N, Tate CG, Vaidehi N.
Lee S, et al.
Biochemistry. 2020 Jun 16;59(23):2125-2134. doi: 10.1021/acs.biochem.0c00183. Epub 2020 Jun 5.
Biochemistry. 2020.
PMID: 32437610
Free PMC article.
The structural and functional properties of G protein-coupled receptors (GPCRs) are often studied in a detergent micellar environment, but many GPCRs tend to denature or aggregate in short alkyl chain detergents. In our previous work [Lee, S., et al. (2016) J. Am. C …
The structural and functional properties of G protein-coupled receptors (GPCRs) are often studied in a detergent micellar environment, but m …