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Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.
Tariq M, de Souza AH, Bensellam M, Chae H, Jaffredo M, Close AF, Deglasse JP, Santos LRB, Buemi A, Mourad NI, Wojtusciszyn A, Raoux M, Gilon P, Broca C, Jonas JC. Tariq M, et al. Among authors: de souza ah. Diabetologia. 2023 Apr;66(4):709-723. doi: 10.1007/s00125-022-05842-y. Epub 2022 Dec 2. Diabetologia. 2023. PMID: 36459178
Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets.
Kim HT, Desouza AH, Umhoefer H, Han J, Anzia L, Sacotte SJ, Williams RA, Blumer JT, Bartosiak JT, Fontaine DA, Baan M, Kibbe CR, Davis DB. Kim HT, et al. Transl Res. 2022 May;243:1-13. doi: 10.1016/j.trsl.2021.10.005. Epub 2021 Nov 3. Transl Res. 2022. PMID: 34740874 Free PMC article.
Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression.
Paul PK, Das R, Drow T, Nylen EA, de Souza AH, Wang Z, Wood MW, Davis DB, Bjorling DE, Galipeau J. Paul PK, et al. Among authors: de souza ah. Am J Transplant. 2022 Nov;22(11):2571-2585. doi: 10.1111/ajt.17162. Epub 2022 Aug 3. Am J Transplant. 2022. PMID: 35897156 Free PMC article.
The Brazilian Toxoplasma gondii strain BRI caused greater inflammation and impairment in anxiogenic behavior in mice, which was reverted by rosuvastatin treatment.
Evangelista FF, de Laet Sant'Ana P, Ferreira WC, Ferreira TA, Dos Santos ML, de Souza AH, de Andrade FAL, da Silva DA, de Barros LD, Colli CM, Nogueira-Melo GA, Costa IN, Falavigna-Guilherme AL. Evangelista FF, et al. Among authors: de souza ah. Parasitol Res. 2023 Dec 20;123(1):64. doi: 10.1007/s00436-023-08038-4. Parasitol Res. 2023. PMID: 38117414
71 results