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Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ. Parsonage G, et al. Among authors: revill ch. Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31. Br J Pharmacol. 2023. PMID: 36457143 Free PMC article.
An in vivo platform for identifying inhibitors of protein aggregation.
Saunders JC, Young LM, Mahood RA, Jackson MP, Revill CH, Foster RJ, Smith DA, Ashcroft AE, Brockwell DJ, Radford SE. Saunders JC, et al. Among authors: revill ch. Nat Chem Biol. 2016 Feb;12(2):94-101. doi: 10.1038/nchembio.1988. Epub 2015 Dec 14. Nat Chem Biol. 2016. PMID: 26656088 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 36784014
Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.
Endesh N, Chuntharpursat-Bon E, Revill C, Yuldasheva NY, Futers TS, Parsonage G, Humphreys N, Adamson A, Morley LC, Cubbon RM, Prasad KR, Foster R, Lichtenstein L, Beech DJ. Endesh N, et al. Liver Int. 2023 Sep;43(9):2026-2038. doi: 10.1111/liv.15646. Epub 2023 Jun 22. Liver Int. 2023. PMID: 37349903 Free PMC article.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. Among authors: revill ch. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253
12 results