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Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ. Parsonage G, et al. Among authors: foster r. Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31. Br J Pharmacol. 2023. PMID: 36457143 Free PMC article.
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.
Li J, Bruns AF, Hou B, Rode B, Webster PJ, Bailey MA, Appleby HL, Moss NK, Ritchie JE, Yuldasheva NY, Tumova S, Quinney M, McKeown L, Taylor H, Prasad KR, Burke D, O'Regan D, Porter KE, Foster R, Kearney MT, Beech DJ. Li J, et al. Among authors: foster r. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1987-94. doi: 10.1161/ATVBAHA.115.305969. Epub 2015 Jul 9. Arterioscler Thromb Vasc Biol. 2015. PMID: 26160956 Free PMC article.
An in vivo platform for identifying inhibitors of protein aggregation.
Saunders JC, Young LM, Mahood RA, Jackson MP, Revill CH, Foster RJ, Smith DA, Ashcroft AE, Brockwell DJ, Radford SE. Saunders JC, et al. Nat Chem Biol. 2016 Feb;12(2):94-101. doi: 10.1038/nchembio.1988. Epub 2015 Dec 14. Nat Chem Biol. 2016. PMID: 26656088 Free PMC article.
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ. Rubaiy HN, et al. Among authors: foster r. J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21. J Biol Chem. 2017. PMID: 28325835 Free PMC article.
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Among authors: foster r. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
2,376 results