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Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.
Suzuki K, Murano T, Shimizu H, Ito G, Nakata T, Fujii S, Ishibashi F, Kawamoto A, Anzai S, Kuno R, Kuwabara K, Takahashi J, Hama M, Nagata S, Hiraguri Y, Takenaka K, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R. Suzuki K, et al. Among authors: hiraguri y. J Gastroenterol. 2018 Sep;53(9):1035-1047. doi: 10.1007/s00535-018-1437-3. Epub 2018 Jan 27. J Gastroenterol. 2018. PMID: 29374777 Free PMC article.
Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-α in the Inflamed Intestinal Epithelia of IBD Patients.
Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Kawamoto A, et al. Among authors: hiraguri y. J Crohns Colitis. 2019 Mar 30;13(4):495-509. doi: 10.1093/ecco-jcc/jjy180. J Crohns Colitis. 2019. PMID: 30395194
Organoid-based regenerative medicine for inflammatory bowel disease.
Okamoto R, Shimizu H, Suzuki K, Kawamoto A, Takahashi J, Kawai M, Nagata S, Hiraguri Y, Takeoka S, Sugihara HY, Yui S, Watanabe M. Okamoto R, et al. Among authors: hiraguri y. Regen Ther. 2020 Jan 13;13:1-6. doi: 10.1016/j.reth.2019.11.004. eCollection 2020 Mar. Regen Ther. 2020. PMID: 31970266 Free PMC article. Review.
TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells.
Anzai S, Kawamoto A, Nagata S, Takahashi J, Kawai M, Kuno R, Kobayashi S, Watanabe S, Suzuki K, Shimizu H, Hiraguri Y, Takeoka S, Sugihara HY, Yui S, Oshima S, Watanabe M, Okamoto R. Anzai S, et al. Among authors: hiraguri y. Biochem Biophys Res Commun. 2020 Apr 9;524(3):533-541. doi: 10.1016/j.bbrc.2020.01.108. Epub 2020 Feb 1. Biochem Biophys Res Commun. 2020. PMID: 32014254
Functional analysis of isoflavones using patient-derived human colonic organoids.
Tsuchiya M, Ito G, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Sugihara HY, Mizutani T, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Tsuchiya M, et al. Among authors: hiraguri y. Biochem Biophys Res Commun. 2021 Jan 20;542:40-47. doi: 10.1016/j.bbrc.2021.01.021. Online ahead of print. Biochem Biophys Res Commun. 2021. PMID: 33486190
Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients.
Kuno R, Ito G, Kawamoto A, Hiraguri Y, Sugihara HY, Takeoka S, Nagata S, Takahashi J, Tsuchiya M, Anzai S, Mizutani T, Shimizu H, Yui S, Oshima S, Tsuchiya K, Watanabe M, Okamoto R. Kuno R, et al. Among authors: hiraguri y. Biochem Biophys Rep. 2021 Jan 11;25:100906. doi: 10.1016/j.bbrep.2020.100906. eCollection 2021 Mar. Biochem Biophys Rep. 2021. PMID: 33490652 Free PMC article.
Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.
Tamura A, Ito G, Matsuda H, Nibe-Shirakihara Y, Hiraoka Y, Kitagawa S, Hiraguri Y, Nagata S, Aonuma E, Otsubo K, Nemoto Y, Nagaishi T, Watanabe M, Okamoto R, Oshima S. Tamura A, et al. Among authors: hiraguri y. Biochem Biophys Res Commun. 2022 Nov 5;628:147-154. doi: 10.1016/j.bbrc.2022.08.046. Epub 2022 Aug 28. Biochem Biophys Res Commun. 2022. PMID: 36087511
Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation.
Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, Inoue M, Nagata S, Okamoto-Uchida Y, Kofuji S, Shimizu H, Ito G, Mizutani T, Yamauchi S, Kinugasa Y, Kano Y, Nemoto Y, Watanabe M, Tsuchiya K, Nishina H, Okamoto R, Yui S. Kobayashi S, et al. Among authors: hiraguri y. Inflamm Regen. 2022 Nov 28;42(1):49. doi: 10.1186/s41232-022-00237-3. Inflamm Regen. 2022. PMID: 36443773 Free PMC article.
Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment.
Watanabe S, Ogasawara N, Kobayashi S, Kirino S, Inoue M, Hiraguri Y, Nagata S, Shimizu H, Ito G, Mizutani T, Nemoto Y, Tsuchiya K, Okamoto R, Watanabe M, Yui S. Watanabe S, et al. Among authors: hiraguri y. J Gastroenterol. 2023 Apr;58(4):379-393. doi: 10.1007/s00535-023-01959-y. Epub 2023 Feb 6. J Gastroenterol. 2023. PMID: 36745238
17 results