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Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation.
Novak A, Laughton D, Lane R, Blackham E, Thomas J, Chatzopoulou E, Wrigglesworth J, Quddus A, Ahmed S, Cousin D, Duffy L, Dubois N, Unitt J, Orban K, Browne E, Ward M, Mycock D, Ieva M, Bland N, George P, Bourne T, Asnagli H, Birch L, Jones G. Novak A, et al. Among authors: laughton d. J Med Chem. 2022 Dec 22;65(24):16640-16650. doi: 10.1021/acs.jmedchem.2c01446. Epub 2022 Nov 30. J Med Chem. 2022. PMID: 36449304
CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma.
Asnagli H, Minet N, Pfeiffer C, Hoeben E, Lane R, Laughton D, Birch L, Jones G, Novak A, Parker AE, Ludwig H, Fischer A, Latour S, Beer PA. Asnagli H, et al. Among authors: laughton d. Hemasphere. 2023 Mar 28;7(4):e864. doi: 10.1097/HS9.0000000000000864. eCollection 2023 Apr. Hemasphere. 2023. PMID: 37008165 Free PMC article.
Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation.
Minet N, Boschat AC, Lane R, Laughton D, Beer P, Asnagli H, Soudais C, Bourne T, Fischer A, Martin E, Latour S. Minet N, et al. Among authors: laughton d. Life Sci Alliance. 2023 Jun 22;6(9):e202302066. doi: 10.26508/lsa.202302066. Print 2023 Sep. Life Sci Alliance. 2023. PMID: 37348953 Free PMC article.
How should initial fit inform soft contact lens prescribing.
Boychev N, Laughton DS, Bharwani G, Ghuman H, Wolffsohn JS. Boychev N, et al. Among authors: laughton ds. Cont Lens Anterior Eye. 2016 Jun;39(3):227-33. doi: 10.1016/j.clae.2015.11.001. Epub 2015 Nov 19. Cont Lens Anterior Eye. 2016. PMID: 26778151 Clinical Trial.
27 results