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Human T cells recognize HLA-DP-bound peptides in two orientations.
Klobuch S, Lim JJ, van Balen P, Kester MGD, de Klerk W, de Ru AH, Pothast CR, Jedema I, Drijfhout JW, Rossjohn J, Reid HH, van Veelen PA, Falkenburg JHF, Heemskerk MHM. Klobuch S, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2214331119. doi: 10.1073/pnas.2214331119. Epub 2022 Nov 29. Proc Natl Acad Sci U S A. 2022. PMID: 36442096 Free PMC article.
Promiscuity of Peptides Presented in HLA-DP Molecules from Different Immunogenicity Groups Is Associated With T-Cell Cross-Reactivity.
Laghmouchi A, Kester MGD, Hoogstraten C, Hageman L, de Klerk W, Huisman W, Koster EAS, de Ru AH, van Balen P, Klobuch S, van Veelen PA, Falkenburg JHF, Jedema I. Laghmouchi A, et al. Among authors: klobuch s. Front Immunol. 2022 Feb 16;13:831822. doi: 10.3389/fimmu.2022.831822. eCollection 2022. Front Immunol. 2022. PMID: 35251023 Free PMC article.
An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells.
Knies D, Klobuch S, Xue SA, Birtel M, Echchannaoui H, Yildiz O, Omokoko T, Guillaume P, Romero P, Stauss H, Sahin U, Herr W, Theobald M, Thomas S, Voss RH. Knies D, et al. Among authors: klobuch s. Oncotarget. 2016 Apr 19;7(16):21199-221. doi: 10.18632/oncotarget.8385. Oncotarget. 2016. PMID: 27028870 Free PMC article.
CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.
Pal SK, Tran B, Haanen JBAG, Hurwitz ME, Sacher A, Tannir NM, Budde LE, Harrison SJ, Klobuch S, Patel SS, Meza L, Dequeant ML, Ma A, He QA, Williams LM, Keegan A, Gurary EB, Dar H, Karnik S, Guo C, Heath H, Yuen RR, Morrow PK, Agarwal N, Srour SA. Pal SK, et al. Among authors: klobuch s. Cancer Discov. 2024 Apr 5:OF1-OF14. doi: 10.1158/2159-8290.CD-24-0102. Online ahead of print. Cancer Discov. 2024. PMID: 38583184
32 results