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Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning.
Sci Rep. 2022 Nov 25;12(1):20329. doi: 10.1038/s41598-022-24472-3.
Sci Rep. 2022.
PMID: 36434021
Free PMC article.
Mitochondrial respiratory chain complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug.
Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK.
Janowska JI, et al.
Toxicol In Vitro. 2020 Jun;65:104794. doi: 10.1016/j.tiv.2020.104794. Epub 2020 Feb 11.
Toxicol In Vitro. 2020.
PMID: 32057835
Free PMC article.
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In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning.
Owiredu S, Ranganathan A, Greenwood JC, Piel S, Janowska JI, Eckmann DM, Kelly M, Ehinger JK, Kilbaugh TJ, Jang DH.
Owiredu S, et al. Among authors: janowska ji.
Toxicol Rep. 2020 Sep 17;7:1263-1271. doi: 10.1016/j.toxrep.2020.09.002. eCollection 2020.
Toxicol Rep. 2020.
PMID: 33005568
Free PMC article.
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Succinate prodrugs as treatment for acute metabolic crisis during fluoroacetate intoxication in the rat.
Piel S, Janowska JI, Ward JL, McManus MJ, Aronowitz DI, Janowski PK, Starr J, Hook JN, Hefti MM, Clayman CL, Elmér E, Hansson MJ, Jang DH, Karlsson M, Ehinger JK, Kilbaugh TJ.
Piel S, et al. Among authors: janowska ji.
Mol Cell Biochem. 2023 Jun;478(6):1231-1244. doi: 10.1007/s11010-022-04589-9. Epub 2022 Oct 25.
Mol Cell Biochem. 2023.
PMID: 36282352
Free PMC article.
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Analysis of Mutational Profile of Hypopharyngeal and Laryngeal Head and Neck Squamous Cell Carcinomas Identifies KMT2C as a Potential Tumor Suppressor.
Machnicki MM, Rzepakowska A, Janowska JI, Pepek M, Krop A, Pruszczyk K, Stawinski P, Rydzanicz M, Grzybowski J, Gornicka B, Wnuk M, Ploski R, Osuch-Wojcikiewicz E, Stoklosa T.
Machnicki MM, et al. Among authors: janowska ji.
Front Oncol. 2022 May 19;12:768954. doi: 10.3389/fonc.2022.768954. eCollection 2022.
Front Oncol. 2022.
PMID: 35664801
Free PMC article.
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