Smith LM - Search Results

1

Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma.

Haney SL, Feng D, Chhonker YS, Varney ML, Williams JT, Smith LM, Ford JB, Murry DJ, Holstein SA. Haney SL, et al. Among authors: smith lm. Drug Dev Res. 2023 Feb;84(1):62-74. doi: 10.1002/ddr.22012. Epub 2022 Nov 25. Drug Dev Res. 2023. PMID: 36433690 Free PMC article.

2

Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.

Haney SL, Upchurch GM, Opavska J, Klinkebiel D, Appiah AK, Smith LM, Heavican TB, Iqbal J, Joshi S, Opavsky R. Haney SL, et al. Among authors: smith lm. Sci Rep. 2016 Sep 28;6:34222. doi: 10.1038/srep34222. Sci Rep. 2016. PMID: 27677595 Free PMC article.

3

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma.

Haney SL, Varney ML, Chhonker YS, Shin S, Mehla K, Crawford AJ, Smith HJ, Smith LM, Murry DJ, Hollingsworth MA, Holstein SA. Haney SL, et al. Among authors: smith hj, smith lm. Oncogene. 2019 Jun;38(26):5308-5320. doi: 10.1038/s41388-019-0794-6. Epub 2019 Mar 27. Oncogene. 2019. PMID: 30918331 Free PMC article.

4

In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution.

Haney SL, Chhonker YS, Varney ML, Talmon G, Smith LM, Murry DJ, Holstein SA. Haney SL, et al. Among authors: smith lm. J Pharmacol Exp Ther. 2019 Nov;371(2):327-338. doi: 10.1124/jpet.119.258624. Epub 2019 Aug 16. J Pharmacol Exp Ther. 2019. PMID: 31420526 Free PMC article.

5

In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.

Haney SL, Varney ML, Chhonker Y, Talmon G, Smith LM, Murry DJ, Holstein SA. Haney SL, et al. Among authors: smith lm. Pharmacol Res. 2021 May;167:105528. doi: 10.1016/j.phrs.2021.105528. Epub 2021 Mar 3. Pharmacol Res. 2021. PMID: 33667685 Free PMC article.

6

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma.

Haney SL, Varney ML, Williams JT, Smith LM, Talmon G, Holstein SA. Haney SL, et al. Among authors: smith lm. Exp Hematol Oncol. 2022 Feb 9;11(1):5. doi: 10.1186/s40164-022-00261-6. Exp Hematol Oncol. 2022. PMID: 35139925 Free PMC article.

7

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis.

Seshacharyulu P, Rachagani S, Muniyan S, Siddiqui JA, Cruz E, Sharma S, Krishnan R, Killips BJ, Sheinin Y, Lele SM, Smith LM, Talmon GA, Ponnusamy MP, Datta K, Batra SK. Seshacharyulu P, et al. Among authors: smith lm. Oncogene. 2019 Jun;38(26):5265-5280. doi: 10.1038/s41388-019-0791-9. Epub 2019 Mar 26. Oncogene. 2019. PMID: 30914801 Free PMC article.

8

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling.

Seshacharyulu P, Halder S, Nimmakayala R, Rachagani S, Chaudhary S, Atri P, Chirravuri-Venkata R, Ouellette MM, Carmicheal J, Gautam SK, Vengoji R, Wang S, Li S, Smith L, Talmon GA, Klute K, Ly Q, Reames BN, Grem JL, Berim L, Padussis JC, Kaur S, Kumar S, Ponnusamy MP, Jain M, Lin C, Batra SK. Seshacharyulu P, et al. EBioMedicine. 2022 Jan;75:103772. doi: 10.1016/j.ebiom.2021.103772. Epub 2021 Dec 28. EBioMedicine. 2022. PMID: 34971971 Free PMC article.

9

A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia.

Smith AL, Eiken AP, Skupa SA, Moore DY, Umeta LT, Smith LM, Lyden ER, D'Angelo CR, Kallam A, Vose JM, Kutateladze TG, El-Gamal D. Smith AL, et al. Among authors: smith lm. Int J Mol Sci. 2022 Jun 16;23(12):6712. doi: 10.3390/ijms23126712. Int J Mol Sci. 2022. PMID: 35743155 Free PMC article.

10

Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.

Rachagani S, Senapati S, Chakraborty S, Ponnusamy MP, Kumar S, Smith LM, Jain M, Batra SK. Rachagani S, et al. Among authors: smith lm. Br J Cancer. 2011 Mar 15;104(6):1038-48. doi: 10.1038/bjc.2011.31. Epub 2011 Mar 1. Br J Cancer. 2011. PMID: 21364589 Free PMC article.

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