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Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons.
Virdi GS, Choi ML, Evans JR, Yao Z, Athauda D, Strohbuecker S, Nirujogi RS, Wernick AI, Pelegrina-Hidalgo N, Leighton C, Saleeb RS, Kopach O, Alrashidi H, Melandri D, Perez-Lloret J, Angelova PR, Sylantyev S, Eaton S, Heales S, Rusakov DA, Alessi DR, Kunath T, Horrocks MH, Abramov AY, Patani R, Gandhi S. Virdi GS, et al. Among authors: gandhi s. NPJ Parkinsons Dis. 2022 Nov 24;8(1):162. doi: 10.1038/s41531-022-00423-7. NPJ Parkinsons Dis. 2022. PMID: 36424392 Free PMC article.
PINK1 protein in normal human brain and Parkinson's disease.
Gandhi S, Muqit MM, Stanyer L, Healy DG, Abou-Sleiman PM, Hargreaves I, Heales S, Ganguly M, Parsons L, Lees AJ, Latchman DS, Holton JL, Wood NW, Revesz T. Gandhi S, et al. Brain. 2006 Jul;129(Pt 7):1720-31. doi: 10.1093/brain/awl114. Epub 2006 May 15. Brain. 2006. PMID: 16702191
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.
Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW. Wood-Kaczmar A, et al. Among authors: gandhi s. PLoS One. 2008 Jun 18;3(6):e2455. doi: 10.1371/journal.pone.0002455. PLoS One. 2008. PMID: 18560593 Free PMC article.
PINK1 cleavage at position A103 by the mitochondrial protease PARL.
Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW. Deas E, et al. Among authors: gandhi s. Hum Mol Genet. 2011 Mar 1;20(5):867-79. doi: 10.1093/hmg/ddq526. Epub 2010 Dec 6. Hum Mol Genet. 2011. PMID: 21138942 Free PMC article.
2,059 results