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Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons.
Virdi GS, Choi ML, Evans JR, Yao Z, Athauda D, Strohbuecker S, Nirujogi RS, Wernick AI, Pelegrina-Hidalgo N, Leighton C, Saleeb RS, Kopach O, Alrashidi H, Melandri D, Perez-Lloret J, Angelova PR, Sylantyev S, Eaton S, Heales S, Rusakov DA, Alessi DR, Kunath T, Horrocks MH, Abramov AY, Patani R, Gandhi S. Virdi GS, et al. Among authors: alessi dr. NPJ Parkinsons Dis. 2022 Nov 24;8(1):162. doi: 10.1038/s41531-022-00423-7. NPJ Parkinsons Dis. 2022. PMID: 36424392 Free PMC article.
Golgi-IP, a tool for multimodal analysis of Golgi molecular content.
Fasimoye R, Dong W, Nirujogi RS, Rawat ES, Iguchi M, Nyame K, Phung TK, Bagnoli E, Prescott AR, Alessi DR, Abu-Remaileh M. Fasimoye R, et al. Among authors: alessi dr. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2219953120. doi: 10.1073/pnas.2219953120. Epub 2023 May 8. Proc Natl Acad Sci U S A. 2023. PMID: 37155866 Free PMC article.
Retromer-dependent lysosomal stress in Parkinson's disease.
Alessi DR, Cullen PJ, Cookson M, Merchant KM, Small SA. Alessi DR, et al. Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220376. doi: 10.1098/rstb.2022.0376. Epub 2024 Feb 19. Philos Trans R Soc Lond B Biol Sci. 2024. PMID: 38368937 Free PMC article. Review.
Development of a highly potent and selective degrader of LRRK2.
Hatcher JM, Zwirek M, Sarhan AR, Vatsan PS, Tonelli F, Alessi DR, Davies P, Gray NS. Hatcher JM, et al. Among authors: alessi dr. Bioorg Med Chem Lett. 2023 Oct 1;94:129449. doi: 10.1016/j.bmcl.2023.129449. Epub 2023 Aug 15. Bioorg Med Chem Lett. 2023. PMID: 37591317
RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses.
Gustavsson EK, Follett J, Trinh J, Barodia SK, Real R, Liu Z, Grant-Peters M, Fox JD, Appel-Cresswell S, Stoessl AJ, Rajput A, Rajput AH, Auer R, Tilney R, Sturm M, Haack TB, Lesage S, Tesson C, Brice A, Vilariño-Güell C, Ryten M, Goldberg MS, West AB, Hu MT, Morris HR, Sharma M, Gan-Or Z, Samanci B, Lis P, Periñan MT, Amouri R, Ben Sassi S, Hentati F; Global Parkinson's Genetics Program (GP2); Tonelli F, Alessi DR, Farrer MJ. Gustavsson EK, et al. Among authors: alessi dr. Lancet Neurol. 2024 Jun;23(6):603-614. doi: 10.1016/S1474-4422(24)00121-2. Epub 2024 Apr 10. Lancet Neurol. 2024. PMID: 38614108 Free article.
Leucine-Rich Repeat Kinases.
Alessi DR, Pfeffer SR. Alessi DR, et al. Annu Rev Biochem. 2024 Apr 15. doi: 10.1146/annurev-biochem-030122-051144. Online ahead of print. Annu Rev Biochem. 2024. PMID: 38621236 Review.
High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.
Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS. Arang N, et al. Among authors: alessi dr. Cell Rep Med. 2023 Nov 21;4(11):101244. doi: 10.1016/j.xcrm.2023.101244. Epub 2023 Oct 18. Cell Rep Med. 2023. PMID: 37858338 Free PMC article.
298 results