Guettler S - Search Results

1

Structural basis of tankyrase activation by polymerization.

Pillay N, Mariotti L, Zaleska M, Inian O, Jessop M, Hibbs S, Desfosses A, Hopkins PCR, Templeton CM, Beuron F, Morris EP, Guettler S. Pillay N, et al. Among authors: guettler s. Nature. 2022 Dec;612(7938):162-169. doi: 10.1038/s41586-022-05449-8. Epub 2022 Nov 23. Nature. 2022. PMID: 36418402 Free PMC article.

2

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.

Mariotti L, Templeton CM, Ranes M, Paracuellos P, Cronin N, Beuron F, Morris E, Guettler S. Mariotti L, et al. Among authors: guettler s. Mol Cell. 2016 Aug 4;63(3):498-513. doi: 10.1016/j.molcel.2016.06.019. Mol Cell. 2016. PMID: 27494558 Free PMC article.

3

Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.

Mariotti L, Pollock K, Guettler S. Mariotti L, et al. Among authors: guettler s. Br J Pharmacol. 2017 Dec;174(24):4611-4636. doi: 10.1111/bph.14038. Epub 2017 Nov 5. Br J Pharmacol. 2017. PMID: 28910490 Free PMC article. Review.

4

Solution NMR assignment of the ARC4 domain of human tankyrase 2.

Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M. Zaleska M, et al. Among authors: guettler s. Biomol NMR Assign. 2019 Apr;13(1):255-260. doi: 10.1007/s12104-019-09887-w. Epub 2019 Mar 7. Biomol NMR Assign. 2019. PMID: 30847846 Free PMC article.

5

Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

Pollock K, Liu M, Zaleska M, Meniconi M, Pfuhl M, Collins I, Guettler S. Pollock K, et al. Among authors: guettler s. Sci Rep. 2019 Dec 13;9(1):19130. doi: 10.1038/s41598-019-55240-5. Sci Rep. 2019. PMID: 31836723 Free PMC article.

6

Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.

Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F. Xiong S, et al. Among authors: guettler s. Structure. 2018 Aug 7;26(8):1101-1115.e6. doi: 10.1016/j.str.2018.05.014. Epub 2018 Jul 5. Structure. 2018. PMID: 29983373 Free PMC article.

7

Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.

Ranes M, Zaleska M, Sakalas S, Knight R, Guettler S. Ranes M, et al. Among authors: guettler s. Mol Cell. 2021 Aug 19;81(16):3246-3261.e11. doi: 10.1016/j.molcel.2021.07.013. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352208 Free PMC article.

8

Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach.

Pollock K, Ranes M, Collins I, Guettler S. Pollock K, et al. Among authors: guettler s. Methods Mol Biol. 2017;1608:445-473. doi: 10.1007/978-1-4939-6993-7_28. Methods Mol Biol. 2017. PMID: 28695526 Free PMC article.

9

AXIN Shapes Tankyrase ARChitecture.

Guettler S. Guettler S. Structure. 2016 Oct 4;24(10):1625-1627. doi: 10.1016/j.str.2016.09.003. Structure. 2016. PMID: 27705813 Free article.

10

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ. Pettitt SJ, et al. Among authors: guettler s. Nat Commun. 2018 May 10;9(1):1849. doi: 10.1038/s41467-018-03917-2. Nat Commun. 2018. PMID: 29748565 Free PMC article.

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