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The free fatty acid-binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron.
Toelzer C, Gupta K, Yadav SKN, Hodgson L, Williamson MK, Buzas D, Borucu U, Powers K, Stenner R, Vasileiou K, Garzoni F, Fitzgerald D, Payré C, Gautam G, Lambeau G, Davidson AD, Verkade P, Frank M, Berger I, Schaffitzel C. Toelzer C, et al. Among authors: davidson ad. Sci Adv. 2022 Nov 25;8(47):eadc9179. doi: 10.1126/sciadv.adc9179. Epub 2022 Nov 23. Sci Adv. 2022. PMID: 36417532 Free PMC article.
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.
Toelzer C, Gupta K, Yadav SKN, Borucu U, Davidson AD, Kavanagh Williamson M, Shoemark DK, Garzoni F, Staufer O, Milligan R, Capin J, Mulholland AJ, Spatz J, Fitzgerald D, Berger I, Schaffitzel C. Toelzer C, et al. Among authors: davidson ad. Science. 2020 Nov 6;370(6517):725-730. doi: 10.1126/science.abd3255. Epub 2020 Sep 21. Science. 2020. PMID: 32958580 Free PMC article.
Neuropilin-1 is a host factor for SARS-CoV-2 infection.
Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi Y. Daly JL, et al. Among authors: davidson ad. Science. 2020 Nov 13;370(6518):861-865. doi: 10.1126/science.abd3072. Epub 2020 Oct 20. Science. 2020. PMID: 33082294 Free PMC article.
Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS-CoV-2 Spike Protein*.
Shoemark DK, Colenso CK, Toelzer C, Gupta K, Sessions RB, Davidson AD, Berger I, Schaffitzel C, Spencer J, Mulholland AJ. Shoemark DK, et al. Among authors: davidson ad. Angew Chem Int Ed Engl. 2021 Mar 22;60(13):7098-7110. doi: 10.1002/anie.202015639. Epub 2021 Feb 22. Angew Chem Int Ed Engl. 2021. PMID: 33469977 Free PMC article.
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals low levels of viral backbone gene transcription alongside very high levels of SARS-CoV-2 S glycoprotein gene transcription.
Almuqrin A, Davidson AD, Williamson MK, Lewis PA, Heesom KJ, Morris S, Gilbert SC, Matthews DA. Almuqrin A, et al. Among authors: davidson ad. Genome Med. 2021 Mar 15;13(1):43. doi: 10.1186/s13073-021-00859-1. Genome Med. 2021. PMID: 33722288 Free PMC article.
The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.
Peacock TP, Goldhill DH, Zhou J, Baillon L, Frise R, Swann OC, Kugathasan R, Penn R, Brown JC, Sanchez-David RY, Braga L, Williamson MK, Hassard JA, Staller E, Hanley B, Osborn M, Giacca M, Davidson AD, Matthews DA, Barclay WS. Peacock TP, et al. Among authors: davidson ad. Nat Microbiol. 2021 Jul;6(7):899-909. doi: 10.1038/s41564-021-00908-w. Epub 2021 Apr 27. Nat Microbiol. 2021. PMID: 33907312
Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2.
Goenka A, Halliday A, Gregorova M, Milodowski E, Thomas A, Williamson MK, Baum H, Oliver E, Long AE, Knezevic L, Williams AJK, Lampasona V, Piemonti L, Gupta K, Di Bartolo N, Berger I, Toye AM, Vipond B, Muir P, Bernatoniene J, Bailey M, Gillespie KM, Davidson AD, Wooldridge L, Rivino L, Finn A. Goenka A, et al. Among authors: davidson ad. Cell Rep Med. 2021 Jul 20;2(7):100327. doi: 10.1016/j.xcrm.2021.100327. Epub 2021 Jun 9. Cell Rep Med. 2021. PMID: 34124701 Free PMC article.
Frontispiz: Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS-CoV-2 Spike Protein.
Shoemark DK, Colenso CK, Toelzer C, Gupta K, Sessions RB, Davidson AD, Berger I, Schaffitzel C, Spencer J, Mulholland AJ. Shoemark DK, et al. Among authors: davidson ad. Angew Chem Weinheim Bergstr Ger. 2021 Mar 22;133(13):10.1002/ange.202181362. doi: 10.1002/ange.202181362. Epub 2021 Mar 15. Angew Chem Weinheim Bergstr Ger. 2021. PMID: 34230706 Free PMC article.
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease.
Avolio E, Carrabba M, Milligan R, Kavanagh Williamson M, Beltrami AP, Gupta K, Elvers KT, Gamez M, Foster RR, Gillespie K, Hamilton F, Arnold D, Berger I, Davidson AD, Hill D, Caputo M, Madeddu P. Avolio E, et al. Among authors: davidson ad. Clin Sci (Lond). 2021 Dec 22;135(24):2667-2689. doi: 10.1042/CS20210735. Clin Sci (Lond). 2021. PMID: 34807265 Free PMC article.
129 results