Childs-Disney JL - Search Results

1

A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G₄C₂)^exp in c9ALS/FTD via the nuclear RNA exosome.

Bush JA, Meyer SM, Fuerst R, Tong Y, Li Y, Benhamou RI, Aikawa H, Zanon PRA, Gibaut QMR, Angelbello AJ, Gendron TF, Zhang YJ, Petrucelli L, Heick Jensen T, Childs-Disney JL, Disney MD. Bush JA, et al. Among authors: childs disney jl. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2210532119. doi: 10.1073/pnas.2210532119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409902 Free PMC article.

2

Improvement of RNA secondary structure prediction using RNase H cleavage and randomized oligonucleotides.

Kauffmann AD, Campagna RJ, Bartels CB, Childs-Disney JL. Kauffmann AD, et al. Nucleic Acids Res. 2009 Oct;37(18):e121. doi: 10.1093/nar/gkp587. Epub 2009 Jul 13. Nucleic Acids Res. 2009. PMID: 19596816 Free PMC article.

3

Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6'-N-acylated kanamycin A.

Disney MD, Childs-Disney JL. Disney MD, et al. Chembiochem. 2007 Apr 16;8(6):649-56. doi: 10.1002/cbic.200600569. Chembiochem. 2007. PMID: 17394189

4

"Supra"molecular recognition of Galectin 1.

Disney MD, Childs-Disney JL. Disney MD, et al. Chem Biol. 2007 Oct;14(10):1095-7. doi: 10.1016/j.chembiol.2007.10.002. Chem Biol. 2007. PMID: 17961821 No abstract available.

5

A small molecule microarray platform to select RNA internal loop-ligand interactions.

Childs-Disney JL, Wu M, Pushechnikov A, Aminova O, Disney MD. Childs-Disney JL, et al. ACS Chem Biol. 2007 Nov 20;2(11):745-54. doi: 10.1021/cb700174r. Epub 2007 Nov 2. ACS Chem Biol. 2007. PMID: 17975888

6

A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections.

Childs-Disney JL, Disney MD. Childs-Disney JL, et al. RNA. 2008 Feb;14(2):390-4. doi: 10.1261/rna.576908. Epub 2007 Dec 7. RNA. 2008. PMID: 18065718 Free PMC article.

7

Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.

Aminova O, Paul DJ, Childs-Disney JL, Disney MD. Aminova O, et al. Biochemistry. 2008 Dec 2;47(48):12670-9. doi: 10.1021/bi8012615. Biochemistry. 2008. PMID: 18991404 Free PMC article.

8

Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3.

Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French JM, Thornton CA, Disney MD. Pushechnikov A, et al. J Am Chem Soc. 2009 Jul 22;131(28):9767-79. doi: 10.1021/ja9020149. J Am Chem Soc. 2009. PMID: 19552411 Free PMC article.

9

Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy.

Lee MM, Childs-Disney JL, Pushechnikov A, French JM, Sobczak K, Thornton CA, Disney MD. Lee MM, et al. J Am Chem Soc. 2009 Dec 2;131(47):17464-72. doi: 10.1021/ja906877y. J Am Chem Soc. 2009. PMID: 19904940 Free PMC article.

10

The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies.

Disney MD, Lee MM, Pushechnikov A, Childs-Disney JL. Disney MD, et al. Chembiochem. 2010 Feb 15;11(3):375-82. doi: 10.1002/cbic.200900716. Chembiochem. 2010. PMID: 20058255 Free PMC article.

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