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Design, synthesis and biological evaluation of novel pyrazolo-pyrimidin-amines as potent and selective BTK inhibitors.
Joshi D, Bahekar R, Soman S, Jadav P, Patel D, Goswami A, Pethani J, Kumar J, Patel J, Sundar R, Goswami P, Goshdastidar K, Patel H, Patel A, Bandyopadhyay D, Chattarjee A, Sharma M, Jain M, Desai R. Joshi D, et al. Among authors: sharma m. Bioorg Chem. 2023 Jan;130:106238. doi: 10.1016/j.bioorg.2022.106238. Epub 2022 Nov 14. Bioorg Chem. 2023. PMID: 36403335
ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.
Ghoshdastidar K, Patel H, Bhayani H, Patel A, Thakkar K, Patel D, Sharma M, Singh J, Mohapatra J, Chatterjee A, Patel D, Bahekar R, Sharma R, Gupta L, Patel N, Giri P, Srinivas NR, Jain M, Bandyopadhyay D, Patel PR, Desai RC. Ghoshdastidar K, et al. Among authors: sharma r, sharma m. Pharmacol Res Perspect. 2020 Aug;8(4):e00565. doi: 10.1002/prp2.565. Pharmacol Res Perspect. 2020. PMID: 32790160 Free PMC article.
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor.
Desai J, Patel B, Gite A, Panchal N, Gite S, Argade A, Kumar J, Sachchidanand S, Bandyopadhyay D, Ghoshdastidar K, Patel H, Chatterjee A, Mahapatra J, Sharma M, Giri P, Kumar S, Jain M, Sharma R, Desai R. Desai J, et al. Among authors: sharma r, sharma m. Bioorg Med Chem Lett. 2022 Jun 15;66:128728. doi: 10.1016/j.bmcl.2022.128728. Epub 2022 Apr 9. Bioorg Med Chem Lett. 2022. PMID: 35413417
Ameliorative potential of aliskiren in experimental colitis in mice.
Patel RB, Prajapati KD, Sonara BM, Sharma MM, Patel HM, Pawar VD, Jain MR. Patel RB, et al. Among authors: sharma mm. Eur J Pharmacol. 2014 Aug 15;737:70-6. doi: 10.1016/j.ejphar.2014.05.009. Epub 2014 May 21. Eur J Pharmacol. 2014. PMID: 24858618
9,606 results