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Design, synthesis and biological evaluation of novel pyrazolo-pyrimidin-amines as potent and selective BTK inhibitors.
Joshi D, Bahekar R, Soman S, Jadav P, Patel D, Goswami A, Pethani J, Kumar J, Patel J, Sundar R, Goswami P, Goshdastidar K, Patel H, Patel A, Bandyopadhyay D, Chattarjee A, Sharma M, Jain M, Desai R. Joshi D, et al. Among authors: patel h, patel j, patel a, patel d. Bioorg Chem. 2023 Jan;130:106238. doi: 10.1016/j.bioorg.2022.106238. Epub 2022 Nov 14. Bioorg Chem. 2023. PMID: 36403335
Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1.
Jain MR, Mohapatra J, Bandhyopadhyay D, Chatterjee A, Ghoshdastidar K, Patel D, Patel A, Bhayani H, Srivastava BK, Shedage SA, Kadam P, Sundar R, Patel H, Giri P, Patel P, Gupta L, Srinivas NR, Patel PR, Desai RC. Jain MR, et al. Among authors: patel h, patel p, patel a, patel pr, patel d. Cancer Chemother Pharmacol. 2018 Oct;82(4):635-647. doi: 10.1007/s00280-018-3653-1. Epub 2018 Jul 25. Cancer Chemother Pharmacol. 2018. PMID: 30046848
ZYBT1, a potent, irreversible Bruton's Tyrosine Kinase (BTK) inhibitor that inhibits the C481S BTK with profound efficacy against arthritis and cancer.
Ghoshdastidar K, Patel H, Bhayani H, Patel A, Thakkar K, Patel D, Sharma M, Singh J, Mohapatra J, Chatterjee A, Patel D, Bahekar R, Sharma R, Gupta L, Patel N, Giri P, Srinivas NR, Jain M, Bandyopadhyay D, Patel PR, Desai RC. Ghoshdastidar K, et al. Among authors: patel h, patel a, patel n, patel pr, patel d. Pharmacol Res Perspect. 2020 Aug;8(4):e00565. doi: 10.1002/prp2.565. Pharmacol Res Perspect. 2020. PMID: 32790160 Free PMC article.
Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19).
Desai J, Patel B, Darji B, Gite A, Panchal N, Bhosale G, Shedage S, Patel S, Kadam P, Patel G, Kumar Srivastava B, Joharapurkar A, Kshirsagar S, Giri P, Bhayani H, Patel A, Ghoshdastidar K, Bandyopadhyay D, Kumar S, Jain M, Sharma R. Desai J, et al. Among authors: patel g, patel a, patel b, patel s. Bioorg Med Chem Lett. 2021 Dec 1;53:128421. doi: 10.1016/j.bmcl.2021.128421. Epub 2021 Oct 27. Bioorg Med Chem Lett. 2021. PMID: 34718128
Single-stranded pre-methylated 5mC adapters uncover the methylation profile of plasma ultrashort Single-stranded cell-free DNA.
Cheng JC, Swarup N, Morselli M, Huang WL, Aziz M, Caggiano C, Kordi M, Patel AA, Chia D, Kim Y, Li F, Wei F, Zaitlen N, Krysan K, Dubinett S, Pellegrini M, Wong DTW. Cheng JC, et al. Among authors: patel aa. Nucleic Acids Res. 2024 May 27:gkae276. doi: 10.1093/nar/gkae276. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38797520
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