Klein MT - Search Results

1

Design and synthesis of a tetracyclic tripeptide mimetic frozen in a polyproline type II (PP2) helix conformation.

Klein MT, Krause BM, Neudörfl JM, Kühne R, Schmalz HG. Klein MT, et al. Org Biomol Chem. 2022 Dec 7;20(47):9368-9377. doi: 10.1039/d2ob01857h. Org Biomol Chem. 2022. PMID: 36385673

2

Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation.

Reuter C, Opitz R, Soicke A, Dohmen S, Barone M, Chiha S, Klein MT, Neudörfl JM, Kühne R, Schmalz HG. Reuter C, et al. Among authors: klein mt. Chemistry. 2015 Jun 1;21(23):8464-70. doi: 10.1002/chem.201406493. Epub 2015 Apr 23. Chemistry. 2015. PMID: 25906737

3

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.

Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Barone M, et al. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184177 Free PMC article.

4

[Talus Fractures - an Update].

Veith N, Braun B, Hell M, Klein MT, Tschernig T, Mörsdorf P, Holstein JH, Pohlemann T. Veith N, et al. Among authors: klein mt. Zentralbl Chir. 2017 Apr;142(2):189-193. doi: 10.1055/s-0042-107950. Epub 2016 Jun 23. Zentralbl Chir. 2017. PMID: 27337117 German.

5

Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.

Klein MT, Vinson PN, Niswender CM. Klein MT, et al. Prog Mol Biol Transl Sci. 2013;115:1-59. doi: 10.1016/B978-0-12-394587-7.00001-4. Prog Mol Biol Transl Sci. 2013. PMID: 23415091 Free PMC article. Review.

6

Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

Tarr JC, Turlington ML, Reid PR, Utley TJ, Sheffler DJ, Cho HP, Klar R, Pancani T, Klein MT, Bridges TM, Morrison RD, Blobaum AL, Xiang Z, Daniels JS, Niswender CM, Conn PJ, Wood MR, Lindsley CW. Tarr JC, et al. Among authors: klein mt. ACS Chem Neurosci. 2012 Nov 21;3(11):884-95. doi: 10.1021/cn300068s. Epub 2012 Jul 18. ACS Chem Neurosci. 2012. PMID: 23173069 Free PMC article.

7

Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study.

Klein MT, Teitler M. Klein MT, et al. Br J Pharmacol. 2012 Jun;166(4):1290-302. doi: 10.1111/j.1476-5381.2012.01868.x. Br J Pharmacol. 2012. PMID: 22260342 Free PMC article.

8

A new approach for studying GPCR dimers: drug-induced inactivation and reactivation to reveal GPCR dimer function in vitro, in primary culture, and in vivo.

Teitler M, Klein MT. Teitler M, et al. Among authors: klein mt. Pharmacol Ther. 2012 Feb;133(2):205-17. doi: 10.1016/j.pharmthera.2011.10.007. Epub 2011 Nov 17. Pharmacol Ther. 2012. PMID: 22119169 Free PMC article. Review.

9

Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships.

Klein MT, Dukat M, Glennon RA, Teitler M. Klein MT, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. doi: 10.1124/jpet.111.179606. Epub 2011 Mar 21. J Pharmacol Exp Ther. 2011. PMID: 21422162 Free PMC article.

10

Antagonist interaction with the human 5-HT(7) receptor mediates the rapid and potent inhibition of non-G-protein-stimulated adenylate cyclase activity: a novel GPCR effect.

Klein MT, Teitler M. Klein MT, et al. Br J Pharmacol. 2011 Apr;162(8):1843-54. doi: 10.1111/j.1476-5381.2010.01194.x. Br J Pharmacol. 2011. PMID: 21198551 Free PMC article.

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