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AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models.
Selles MC, Fortuna JTS, Cercato MC, Santos LE, Domett L, Bitencourt ALB, Carraro MF, Souza AS, Janickova H, Azevedo CV, Campos HC, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Epstein AL, Salvetti A, Longo BM, Arancio O, Klein WL, Sebollela A, De Felice FG, Jerusalinsky DA, Ferreira ST. Selles MC, et al. Among authors: fortuna jts. Mol Ther. 2023 Feb 1;31(2):409-419. doi: 10.1016/j.ymthe.2022.11.002. Epub 2022 Nov 11. Mol Ther. 2023. PMID: 36369741 Free PMC article.
Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.
Fortuna JTS, Gralle M, Beckman D, Neves FS, Diniz LP, Frost PS, Barros-Aragão F, Santos LE, Gonçalves RA, Romão L, Zamberlan DC, Soares FAA, Braga C, Foguel D, Gomes FCA, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP. Fortuna JTS, et al. Behav Brain Res. 2017 Aug 30;333:150-160. doi: 10.1016/j.bbr.2017.06.047. Epub 2017 Jun 29. Behav Brain Res. 2017. PMID: 28668282
Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of Aβ Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model.
Selles MC, Fortuna JTS, Zappa-Villar MF, de Faria YPR, Souza AS, Suemoto CK, Leite REP, Rodriguez RD, Grinberg LT, Reggiani PC, Ferreira ST. Selles MC, et al. Among authors: fortuna jts. Mol Neurobiol. 2020 Mar;57(3):1473-1483. doi: 10.1007/s12035-019-01827-y. Epub 2019 Nov 23. Mol Neurobiol. 2020. PMID: 31760608 Free PMC article.
Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α.
Melo HM, Seixas da Silva GDS, Sant'Ana MR, Teixeira CVL, Clarke JR, Miya Coreixas VS, de Melo BC, Fortuna JTS, Forny-Germano L, Ledo JH, Oliveira MS, Figueiredo CP, Pardossi-Piquard R, Checler F, Delgado-García JM, Gruart A, Velloso LA, Balthazar MLF, Cintra DE, Ferreira ST, De Felice FG. Melo HM, et al. Among authors: fortuna jts. Cell Rep. 2020 Feb 18;30(7):2180-2194.e8. doi: 10.1016/j.celrep.2020.01.072. Cell Rep. 2020. PMID: 32075735 Free article.
Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease.
Lyra E Silva NM, Gonçalves RA, Pascoal TA, Lima-Filho RAS, Resende EPF, Vieira ELM, Teixeira AL, de Souza LC, Peny JA, Fortuna JTS, Furigo IC, Hashiguchi D, Miya-Coreixas VS, Clarke JR, Abisambra JF, Longo BM, Donato J Jr, Fraser PE, Rosa-Neto P, Caramelli P, Ferreira ST, De Felice FG. Lyra E Silva NM, et al. Among authors: fortuna jts. Transl Psychiatry. 2021 Apr 28;11(1):251. doi: 10.1038/s41398-021-01349-z. Transl Psychiatry. 2021. PMID: 33911072 Free PMC article.
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress.
Rossi ÁD, de Araújo JLF, de Almeida TB, Ribeiro-Alves M, de Almeida Velozo C, Almeida JM, de Carvalho Leitão I, Ferreira SN, da Silva Oliveira J, Alves HJ, Scheid HT, Faffe DS, Galliez RM, de Ávila RE, Resende GG, Teixeira MM; COVID-19 UFRJ Workgroup; da Costa Ferreira Júnior O, Castiñeiras TMPP, Souza RP, Tanuri A, Aguiar RS, Barroso SPC, Cardoso CC. Rossi ÁD, et al. Sci Rep. 2021 May 6;11(1):9658. doi: 10.1038/s41598-021-88944-8. Sci Rep. 2021. PMID: 33958627 Free PMC article.