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Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).
Int J Mol Sci. 2022 Oct 31;23(21):13261. doi: 10.3390/ijms232113261.
Int J Mol Sci. 2022.
PMID: 36362047
Free PMC article.
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
Chan KF, Wong IL, Kan JW, Yan CS, Chow LM, Chan TH.
Chan KF, et al.
J Med Chem. 2012 Mar 8;55(5):1999-2014. doi: 10.1021/jm201121b. Epub 2012 Feb 22.
J Med Chem. 2012.
PMID: 22320402
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A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo.
Yan CS, Wong IL, Chan KF, Kan JW, Chong TC, Law MC, Zhao Y, Chan SW, Chan TH, Chow LM.
Yan CS, et al.
Mol Pharm. 2015 Oct 5;12(10):3507-17. doi: 10.1021/mp500770e. Epub 2015 Aug 27.
Mol Pharm. 2015.
PMID: 26291333
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Boosting the efficacy of anti-MRSA β-lactam antibiotics via an easily accessible, non-cytotoxic and orally bioavailable FtsZ inhibitor.
Lui HK, Gao W, Cheung KC, Jin WB, Sun N, Kan JWY, Wong ILK, Chiou J, Lin D, Chan EWC, Leung YC, Chan TH, Chen S, Chan KF, Wong KY.
Lui HK, et al. Among authors: kan jwy.
Eur J Med Chem. 2019 Feb 1;163:95-115. doi: 10.1016/j.ejmech.2018.11.052. Epub 2018 Nov 24.
Eur J Med Chem. 2019.
PMID: 30503946
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Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel.
Kan JWY, Yan CSW, Wong ILK, Su X, Liu Z, Chan TH, Chow LMC.
Kan JWY, et al.
Int J Mol Sci. 2022 Dec 4;23(23):15299. doi: 10.3390/ijms232315299.
Int J Mol Sci. 2022.
PMID: 36499627
Free PMC article.
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Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04.
Liu Z, Wong ILK, Sang J, Liu F, Yan CSW, Kan JWY, Chan TH, Chow LMC.
Liu Z, et al. Among authors: kan jwy.
J Med Chem. 2023 May 11;66(9):6160-6183. doi: 10.1021/acs.jmedchem.2c02005. Epub 2023 Apr 25.
J Med Chem. 2023.
PMID: 37098275
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