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Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: kornienko a. Eur J Med Chem. 2015 Oct 20;103:226-37. doi: 10.1016/j.ejmech.2015.08.047. Epub 2015 Aug 29. Eur J Med Chem. 2015. PMID: 26360047 Free PMC article.
Synthetic and Biological Studies of Sesquiterpene Polygodial: Activity of 9-Epipolygodial against Drug-Resistant Cancer Cells.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: kornienko a. ChemMedChem. 2015 Dec;10(12):2014-26. doi: 10.1002/cmdc.201500360. Epub 2015 Oct 5. ChemMedChem. 2015. PMID: 26434977 Free PMC article.
Polygodial analog induces apoptosis in LNCaP prostate cancer cells.
Dasari S, Samy ALPA, Narvekar P, Dontaraju VS, Dasari R, Kornienko A, Munirathinam G. Dasari S, et al. Among authors: kornienko a. Eur J Pharmacol. 2018 Jun 5;828:154-162. doi: 10.1016/j.ejphar.2018.03.029. Epub 2018 Mar 20. Eur J Pharmacol. 2018. PMID: 29572068 Free PMC article.
Isatin derivatives with activity against apoptosis-resistant cancer cells.
Evdokimov NM, Magedov IV, McBrayer D, Kornienko A. Evdokimov NM, et al. Among authors: kornienko a. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1558-1560. doi: 10.1016/j.bmcl.2016.02.015. Epub 2016 Feb 8. Bioorg Med Chem Lett. 2016. PMID: 26883150 Free PMC article.
212 results