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The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner.
Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. Sanz-Castillo B, et al. Among authors: malumbres m. EMBO J. 2023 Jan 16;42(2):e110833. doi: 10.15252/embj.2022110833. Epub 2022 Nov 10. EMBO J. 2023. PMID: 36354735 Free PMC article.
Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.
Álvarez-Fernández M, Sánchez-Martínez R, Sanz-Castillo B, Gan PP, Sanz-Flores M, Trakala M, Ruiz-Torres M, Lorca T, Castro A, Malumbres M. Álvarez-Fernández M, et al. Among authors: malumbres m. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17374-9. doi: 10.1073/pnas.1310745110. Epub 2013 Oct 7. Proc Natl Acad Sci U S A. 2013. PMID: 24101512 Free PMC article.
An Atypical Oncogene Within the Atypical E2Fs.
Álvarez-Fernández M, Malumbres M. Álvarez-Fernández M, et al. Among authors: malumbres m. J Natl Cancer Inst. 2015 Jun 18;107(9):djv180. doi: 10.1093/jnci/djv180. Print 2015 Sep. J Natl Cancer Inst. 2015. PMID: 26089542 Free PMC article. No abstract available.
AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest.
Doménech E, Maestre C, Esteban-Martínez L, Partida D, Pascual R, Fernández-Miranda G, Seco E, Campos-Olivas R, Pérez M, Megias D, Allen K, López M, Saha AK, Velasco G, Rial E, Méndez R, Boya P, Salazar-Roa M, Malumbres M. Doménech E, et al. Among authors: malumbres m. Nat Cell Biol. 2015 Oct;17(10):1304-16. doi: 10.1038/ncb3231. Epub 2015 Aug 31. Nat Cell Biol. 2015. PMID: 26322680
A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy.
Sánchez-Martínez R, Cruz-Gil S, Gómez de Cedrón M, Álvarez-Fernández M, Vargas T, Molina S, García B, Herranz J, Moreno-Rubio J, Reglero G, Pérez-Moreno M, Feliu J, Malumbres M, Ramírez de Molina A. Sánchez-Martínez R, et al. Among authors: malumbres m. Oncotarget. 2015 Nov 17;6(36):38719-36. doi: 10.18632/oncotarget.5340. Oncotarget. 2015. PMID: 26451612 Free PMC article.
Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.
de Cárcer G, Wachowicz P, Martínez-Martínez S, Oller J, Méndez-Barbero N, Escobar B, González-Loyola A, Takaki T, El Bakkali A, Cámara JA, Jiménez-Borreguero LJ, Bustelo XR, Cañamero M, Mulero F, de Los Ángeles Sevilla M, Montero MJ, Redondo JM, Malumbres M. de Cárcer G, et al. Among authors: malumbres m. Nat Med. 2017 Aug;23(8):964-974. doi: 10.1038/nm.4364. Epub 2017 Jul 10. Nat Med. 2017. PMID: 28692064
Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.
Álvarez-Fernández M, Sanz-Flores M, Sanz-Castillo B, Salazar-Roa M, Partida D, Zapatero-Solana E, Ali HR, Manchado E, Lowe S, VanArsdale T, Shields D, Caldas C, Quintela-Fandino M, Malumbres M. Álvarez-Fernández M, et al. Among authors: malumbres m. Cell Death Differ. 2018 May;25(5):828-840. doi: 10.1038/s41418-017-0024-0. Epub 2017 Dec 11. Cell Death Differ. 2018. PMID: 29229993 Free PMC article.
222 results